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Titolo:
Age-related changes in regional activation during working memory in young adults: An fMRI study
Autore:
Adler, CM; Holland, SK; Enseleit, S; Strakowski, SM;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Bipolar & Psychot Disorders Res Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Program, Cincinnati, OH 45267 USA Univ Cincinnati, Childrens Hosp, Med Ctr, Imaging Res Ctr, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA r, Imaging Res Ctr, Cincinnati, OH USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 252 - 257
SICI:
0887-4476(200112)42:4<252:ACIRAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; CARD SORTING TEST; HIPPOCAMPAL-FORMATION; ALZHEIMERS-DISEASE; NEURAL SYSTEM; RETROSPECTIVE ESTIMATION; OXYGEN-CONSUMPTION; PREFRONTAL CORTEX; FUNCTIONAL MRI;
Keywords:
neuroimaging; working memory; n-back; human; age; cognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, CM Univ Cincinnati, Coll Med, Dept Psychiat, Bipolar & Psychot Disorders Res Program, 231 Bethesda Ave, Cincinnati, OH 45267 USA Univ Cincinnati 231 Bethesda Ave Cincinnati OH USA 45267 267 USA
Citazione:
C.M. Adler et al., "Age-related changes in regional activation during working memory in young adults: An fMRI study", SYNAPSE, 42(4), 2001, pp. 252-257

Abstract

Several lines of evidence suggest that working memory diminishes with advancing age, with concomitant functional changes in associated neuronal activation in frontal cortical regions and hippocampi. No studies to date, however, have investigated age-related changes in neuronal activation in these regions during performance of a working memory task in younger subjects without working memory deficits. In this study, we utilized fMRI to examine changes in brain activation with increasing age in specific regions-of-interest. Eleven healthy subjects performed a "two-back" working memory task and amatched "zero-back" attention task during fMRI. There was no association between age and performance on either task. Left hippocampal activation significantly correlated with age (P = 0.01) and right hippocampal activation showed an association with age (P = 0.09). This study demonstrates that increasing age is associated with increased activation of hippocampus even in young patients without evidence of working memory deficits and suggests thatfunctional changes may precede overt evidence of working memory deficits. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:14:39