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Titolo:
Topology of ionotropic glutamate receptors in brains of heterozygous and homozygous weaver mutant mice
Autore:
Reader, TA; Senecal, J;
Indirizzi:
Univ Montreal, Fac Med, Dept Physiol, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 213 - 233
SICI:
0887-4476(200112)42:4<213:TOIGRI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; ACID BINDING-SITES; SUBUNIT MESSENGER-RNAS; DOPAMINERGIC MESENCEPHALIC NEURONS; HIGH-AFFINITY KAINATE; H-3 MK-801 BINDING; RAT-BRAIN; QUANTITATIVE AUTORADIOGRAPHY; CEREBELLAR CORTEX; PURKINJE-CELLS;
Keywords:
NMDA; MK-801; AMPA; kainic acid; autoradiography;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Reader, TA Univ Montreal, Fac Med, Dept Physiol, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 l, PQ H3C 3J7, Canada
Citazione:
T.A. Reader e J. Senecal, "Topology of ionotropic glutamate receptors in brains of heterozygous and homozygous weaver mutant mice", SYNAPSE, 42(4), 2001, pp. 213-233

Abstract

In weaver mice, mutation of a G-protein inwardly rectifying K+ channel leads to a cerebellar developmental anomaly characterized by granule and Purkinje cell loss and, in addition, degeneration of dopaminergic neurons. To evaluate other deficits, ionotropic glutamate receptors sensitive to N-methyl-D-aspartate (NMDA), amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainic acid (KA) were examined by autoradiography with [H-3] MK-801, [H-3] AMPA, and [H-3] KA. These surveys were carried out in selected areas of cerebral cortex, hippocampus and related limbic regions, basal ganglia, thalamus, hypothalamus, brainstem, and cerebellum from heterozygous (wv/) and homozygous (wv/wv) weaver mutants, and compared to wild-type (+/+) mice. In wv/+ and wv/wv mutants, NMDA receptor levels were lower in corticalareas, septum, hippocampus, subiculum, neostriatum, nucleus accumbens, superior colliculus, and in the cerebellar granular layer. Densities of KA receptors were lower in cortical areas, hippocampus, limbic system structures,neostriatum, nucleus accumbens, thalamus and hypothalamus, superior and inferior colliculi, and cerebellar cortex of wv/wv mutants. Levels of AMPA receptors in the weaver were higher than in +/+ mice, particularly in somatosensory and piriform cortices and periaqueductal gray of wv/+, and in somatosensory cortex, CA1 field of Ammon's horn and cerebellar granular layer of wv/wv. Abnormal developmental signals, aberrant cellular responses, or a distorted balance between neurotransmitter interactions may underlie such widespread and reciprocal glutamate receptor alterations, while in the case ofcerebellar cortex, NMDA receptors are lacking due to a massive disappearance of cerebellar granule cells and some loss of Purkinje neurons. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:21:36