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Titolo:
Serotonin(1A) receptor ligands act on norepinephrine neuron firing throughexcitatory amino acid and GABA(A) receptors: A microiontophoretic study inthe rat locus coeruleus
Autore:
Szabo, ST; Blier, P;
Indirizzi:
Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 ain Inst, Gainesville, FL 32610 USA McGill Univ, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Unit, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 203 - 212
SICI:
0887-4476(200112)42:4<203:SRLAON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-EVOKED ACTIVATION; ROSTRAL VENTRAL MEDULLA; NORADRENERGIC NEURONS; NUCLEUS PARAGIGANTOCELLULARIS; 5-HYDROXYTRYPTAMINE SYSTEM; CERULEUS NEURONS; 5-HT2 RECEPTORS; BRAIN; ANTAGONIST; MODULATION;
Keywords:
5-HT1A; 5-HT2A; GABA; kainate; glutamate; anxiety disorders; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Blier, P Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
S.T. Szabo e P. Blier, "Serotonin(1A) receptor ligands act on norepinephrine neuron firing throughexcitatory amino acid and GABA(A) receptors: A microiontophoretic study inthe rat locus coeruleus", SYNAPSE, 42(4), 2001, pp. 203-212

Abstract

It was previously shown that the excitatory effect of the 5-HT1A agonist 8-OH-DPAT on firing activity of locus coeruleus (LC) norepinephrine (NE) neurons and the inhibitory action of the 5-HT1A antagonist WAY 100,635 are dependent on the presence of 5-HT neurons, whereas the inhibitory action of the 5-HT2 agonist DOI is not. Using in vivo extracellular unitary recordings performed in anesthetized rats, iontophoretic applications of the excitatory amino acid antagonist kynurenate attenuated the enhancement in firing produced by glutamate and kainate. In contrast, GABA applications decreased the firing activity of NE neurons which was attenuated by the enhancement produced by glutamate and kainate. In contrast, GABA applications decreased the firing activity of NE neurons which was attenuated by the GABA(A) receptor antagonist bicuculline. 8-OH-DPAT (10-60 mug kg(-1), i.v.) produced a dose-dependent enhancement in the firing activity of NE neurons that was abolished in the presence of kynurenate application. The selective 5-HT1A receptor antagonist WAY 100,635 (100 mug kg(-1), i.v.) suppressed NE firing whichwas reversed by the selective 5-HT2A antagonist MDL 100,907 (200 mug kg(-1), i.v.). In the presence of bicuculline, the inhibitory effect of WAY 100,635 was blunted. These results suggest that WAY 100,635 mainly attenuates NE neuron firing by blocking inhibitory 5-HT1A receptors on glutamatergic neurons, thereby enhancing glutamate release and activating excitatory amino acid receptors, possibly of the kainate subtype, on 5-HT terminals. The ensuing increased 5-HT release would then act on excitatory 5-HT(2)A receptorson GABA neurons that would ultimately mediate the inhibition of NE neurons. The prevention of the excitatory action of 8-OH-DPAT on NE neuron firing by kynurenate is also consistent with this neurocircuitry. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:18:04