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Titolo:
Excitatory synapses from CA3 pyramidal cells onto neighboring pyramidal cells differ from those onto inhibitory interneurons
Autore:
Aaron, GB; Dichter, MA;
Indirizzi:
Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 199 - 202
SICI:
0887-4476(200112)42:4<199:ESFCPC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL SLICE CULTURES; RAT HIPPOCAMPUS; NEURONS; RECORDINGS; DEPRESSION; MODULATION; RELEASE;
Keywords:
hippocampus; epilepsy; AMPA receptor; stratum oriens; EPSC; short-term plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Dichter, MA Univ Penn, Dept Neurol, Room 467 Stemmler Hall,3450 Hamilton Walk, Philadelphia, PA 19104 USA Univ Penn Room 467 Stemmler Hall,3450 Hamilton Walk Philadelphia PA USA 19104
Citazione:
G.B. Aaron e M.A. Dichter, "Excitatory synapses from CA3 pyramidal cells onto neighboring pyramidal cells differ from those onto inhibitory interneurons", SYNAPSE, 42(4), 2001, pp. 199-202

Abstract

The glutamatergic pyramidal cell (PYR) to pyramidal cell synapse was compared to the PYR to inhibitory interneuron (INT) synapse in area CA3 of rat hippocampal roller-tube cultures. Paired-pulses and tetanic stimulations of a presynaptic PYR were conducted utilizing dual whole-cell patch-clamp recordings of either two PYRs or of a PYR and visually identified stratum oriens INT. Differences in synaptic characteristics were observed, depending on the postsynaptic target cell. Across cell pairs the variation of EPSC amplitudes was much larger for postsynaptic PYRs than for INTs. EPSCs recorded from INTs had faster rise times and shorter decays than those recorded in PYRs. There were also differences in the short-term plasticity of these synapses. Dual PYR:PYR recordings during paired-pulse stimulation at 100 ms interstimulus intervals demonstrated no modulation of EPSC amplitudes, while PYR:INT synapses showed paired-pulse depression. During trains of action potentials, the PYR: PYR EPSCs followed the presynaptic action potential train reliably, with little depression of EPSCs, while PYR:INT EPSCs demonstratedfailures of transmission or profound depression after the initial EPSC. These results indicate multiple differences at both the pre- and postsynapticlevel in the characteristics of pyramidal cell synapses that depend on thepostsynaptic target's identity as either PYR or INT. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:51:09