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Titolo:
Assessment and comparison of the buffering power of Cimetidine Merck, Tagamet and Azantac effervescent tablets
Autore:
Menet, MC; Dugay, A; Lamarque, D; Guyon, F;
Indirizzi:
Fac Pharm Paris V, Chim Analyt Lab, F-75270 Paris 06, France Fac Pharm Paris V Paris France 06 m Analyt Lab, F-75270 Paris 06, France Hop Henri Mondor, Serv Hepatogastroenterol, F-94000 Creteil, France Hop Henri Mondor Creteil France F-94000 enterol, F-94000 Creteil, France
Titolo Testata:
STP PHARMA SCIENCES
fascicolo: 4, volume: 11, anno: 2001,
pagine: 305 - 309
SICI:
1157-1489(200107/08)11:4<305:AACOTB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-SUBJECTS; INTRAGASTRIC PH; GASTRIC-ACIDITY; RANITIDINE; PLACEBO;
Keywords:
effervescent mixture; anti-H2; gastroesophageal reflux; acid-base pair; buffering powers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Menet, MC Fac Pharm Paris V, Chim Analyt Lab, 4 Ave Observ, F-75270 Paris 06, France Fac Pharm Paris V 4 Ave Observ Paris France 06 Paris 06, France
Citazione:
M.C. Menet et al., "Assessment and comparison of the buffering power of Cimetidine Merck, Tagamet and Azantac effervescent tablets", STP PHARM S, 11(4), 2001, pp. 305-309

Abstract

Anti-secretory treatment with H2 receptor antagonists (cimetidine and ranitidine) is the first-line therapy for the functional manifestations of gastroesophageal reflux (GER). Anti-secretory anti-H2 drugs act after several tens of minutes. In order to obtain more rapid relief for patients, effervescent forms of anti-H2 substances (granules and tablets) are formulated withexcipients that can increase gastric pH rap idly, before a systemic anti-secretory action. Neutralization curves were used to model variations of gastric pH versus time and to determine its value 10 min after administering the tablet, just before the pharmacological action of the anti-H2 compounds. Two parameters were then used to assess the buffering effect of the excipients in the different products: buffering powers and the acid neutralizing capacity (ANC) defined by the USP 24(th) edition. The results showed that the buffering effect is correlated with the quantity of buffers present in the tablets. Among the three products indicated for gastroesophageal reflux,Cimetidine Merck 200 mg, Azantac 75 mg and Tagamet effervescent 200 mg, Tagamet was found to lead to the most rapid and long-lasting increase of gastric pH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:17:37