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Titolo:
Formulation and evaluation of buccal mucoadhesive patches of terbutaline sulphate
Autore:
Sharma, P; Hamsa, V;
Indirizzi:
Govt Coll Pharm, Dept Pharmaceut, Bangalore 645001, Karnataka, India Govt Coll Pharm Bangalore Karnataka India 645001 645001, Karnataka, India
Titolo Testata:
STP PHARMA SCIENCES
fascicolo: 4, volume: 11, anno: 2001,
pagine: 275 - 281
SICI:
1157-1489(200107/08)11:4<275:FAEOBM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-DELIVERY; MECHANISMS; POLYMERS; CHITOSAN; RELEASE; SYSTEMS; MUCOSA;
Keywords:
terbutaline sulphate; buccal mucoadhesive; in vitro permeation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, P Govt Coll Pharm, Dept Pharmaceut, 2 Miss Rd, Bangalore 645001, Karnataka, India Govt Coll Pharm 2 Miss Rd Bangalore Karnataka India 645001 India
Citazione:
P. Sharma e V. Hamsa, "Formulation and evaluation of buccal mucoadhesive patches of terbutaline sulphate", STP PHARM S, 11(4), 2001, pp. 275-281

Abstract

Terbutaline sulphate (sympathominietic, anti-asthmatic) undergoes extensive first-pass metabolism on oral ingestion. Buccal mucoadhesive patches of terbutaline sulphate were prepared as an alternative dosage form using six polymers in different combinations and proportions. The backing membrane wasmade of a polyglassine sheet or ethylcellulose. The patches were evaluatedfor physical (appearance, tensile strength, thickness uniformity, weight, endurance and scanning electron micrograph), chemical (drug content, interexcipient incompatibility and accelerated stability studies) and biological (bioadhesion, dissolution and in vitro permeation through hamster cheek mucosa) parameters. In vitro permeation assembly was designed to observe drug transport through the biological membrane (hamster-cheek pouch mucosa). Buccal patches with sodium carboxymethylcellulose showed good bioadhesive strength. Patches with a polyglassine backing membrane had a higher tensile strength and provided a more efficient unidirectional flow compared with the ethylcellulose backing membranes. The dissolution data of terbutaline sulphate from polyglassine patches were found to fit zero-order release kinetics and diffusion was non-Fickian in nature. No drug excipient or interexcipient incompatibility could be traced for five weeks. The PG26 formulation was studied extensively using SEM, dissolution, in vitro permeation and stability studies and appears to be a suitable fast-releasing buccal patch for terbutaline sulphate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:48:40