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Titolo:
A method to assess the proportion of treatment effect explained by a surrogate endpoint
Autore:
Li, ZQ; Meredith, MP; Hoseyni, MS;
Indirizzi:
Procter & Gamble Co, Dept Biometr & Stat Sci, Mason, OH 45040 USA Procter & Gamble Co Mason OH USA 45040 tr & Stat Sci, Mason, OH 45040 USA
Titolo Testata:
STATISTICS IN MEDICINE
fascicolo: 21, volume: 20, anno: 2001,
pagine: 3175 - 3188
SICI:
0277-6715(20011115)20:21<3175:AMTATP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; END-POINTS; POSTMENOPAUSAL OSTEOPOROSIS; PAGETS-DISEASE; RISEDRONATE; BONE; VALIDATION; FRACTURES; CRITERIA; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Li, ZQ Procter & Gamble Co, Dept Biometr & Stat Sci, 8700 Mason MontgomeryRd,Box2199, Mason, OH 45040 USA Procter & Gamble Co 8700 Mason Montgomery Rd,Box 2199 Mason OH USA 45040
Citazione:
Z.Q. Li et al., "A method to assess the proportion of treatment effect explained by a surrogate endpoint", STAT MED, 20(21), 2001, pp. 3175-3188

Abstract

Randomized clinical trials are the standard for evaluating new drugs, devices and procedures. Traditional clinical trials entail not only considerable expense, but require considerable time to complete. The use of surrogate endpoints constitates an effort to control cost and completion time for clinical trials. We propose a method to quantify the proportion of treatment effect explained by a surrogate endpoint based on a general model setting which includes the commonly used linear, logistic and Cox regression models. The interpretation of this quantitative measure is facilitated by graphicaldisplays. To reduce the variability associated with the estimate, a meta-analytic approach is proposed based on random effects models. An example using real clinical trial data is given to illustrate the proposed procedures. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:49:15