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Titolo:
Liver-targeting macromolecular MRI contrast agents
Autore:
Yang, GP; Zhuo, RX; Xu, MY; Li, LY; Tang, YF;
Indirizzi:
Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 t, Wuhan 430072, Peoples R China Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance &Atom & Mol Phys, Wuhan 430071, Peoples R China Chinese Acad Sci Wuhan Peoples R China 430071 an 430071, Peoples R China
Titolo Testata:
SCIENCE IN CHINA SERIES B-CHEMISTRY
fascicolo: 4, volume: 44, anno: 2001,
pagine: 344 - 352
SICI:
1001-652X(200108)44:4<344:LMMCA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEXES;
Keywords:
polyaspartamide; gadolinium complexes; magnetic resonance imaging (MRI); relaxivity; liver-targeting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Zhuo, RX Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 430072, Peoples R China
Citazione:
G.P. Yang et al., "Liver-targeting macromolecular MRI contrast agents", SCI CHINA B, 44(4), 2001, pp. 344-352

Abstract

Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetriaminepentaacetic acid monopyridoxamine group (DTPA-PM)into poly-alpha, beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) and poly-alpha, beta-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd(III) contents. These macromolecular ligands and their gadolinium complexes were characterized by H-1 NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging ofthe liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MR] contrast agents containing pyridoxamine exhibit liver-targeting property.

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Documento generato il 13/07/20 alle ore 17:38:09