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Titolo:
Transarterial chemoembolization in hepatocellular carcinoma: technique, indication, results
Autore:
Zangos, S; Gille, T; Eichler, K; Engelmann, K; Woitaschek, D; Balzer, JO; Mack, MG; Thalhammer, A; Vogl, TJ;
Indirizzi:
Univ Frankfurt, Inst Diagnost & Intervent Radiol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 iol, D-60590 Frankfurt, Germany
Titolo Testata:
RADIOLOGE
fascicolo: 10, volume: 41, anno: 2001,
pagine: 906 - 914
SICI:
0033-832X(200110)41:10<906:TCIHCT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Soggetto:
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; PERCUTANEOUS ETHANOL INJECTION; IODIZED-OIL; PROGNOSTIC FACTORS; LIVER-TUMORS; MULTIVARIATE-ANALYSIS; RANDOMIZED TRIAL; THERAPY; CIRRHOSIS; PHARMACOKINETICS;
Keywords:
hepatocellular carcinoma; transarterial chemoembolization; intervention; tumor ablation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Zangos, S Univ Frankfurt, Inst Diagnost & Intervent Radiol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 ny
Citazione:
S. Zangos et al., "Transarterial chemoembolization in hepatocellular carcinoma: technique, indication, results", RADIOLOGE, 41(10), 2001, pp. 906-914

Abstract

Background. At time of diagnosis 80% of the patients with hepatocellular carcinoma (HCC) could not be treated with surgical treatments, so that transarterial chemoembolization (TACE) was used as an neoadjuvant or palliative treatment modality. Material and methods. 60 patients were treated with 217 TACE courses, in the mean 3.6 TACE treatments per patient with an 4 week interval. TACE was performed with a dispersion of lipiodol, mitomycin C and spherex. 11 patients (18.3%) were treated in a neoadjuvant protocol with successful ablation. Liplodol retention and size of the tumors were evaluated by CT and MRI. Results. 60 patients were successful treated with TACE. After treatment a primary high liplodol retention was displayed and in 68 (63.3%) patients a reduction of the tumor size and in 11 (20%) patients a reduction of tumor growth rate was noted. The 1 year survival rate was 59%. After response to TACE and reducing the tumor size 11 patients could be treated with MR-guided LITT 4 to 6 weeks post embolization. Conclusion. Chemoembolization is a minimal invasive and outpatient treatment protocol for HCC. TACE might be indicated as a palliative treatment to control the diseased liver. If repeated TACE alteres the size and structure of primary unresectable HCCTACE expands the indication for MR-guided LITT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:26:14