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Titolo:
COLD-ADAPTED LIVE ATTENUATED INFLUENZA VACCINES DEVELOPED IN RUSSIA -CAN THEY CONTRIBUTE TO MEETING THE NEEDS FOR INFLUENZA CONTROL IN OTHER COUNTRIES
Autore:
KENDAL AP;
Indirizzi:
EMORY UNIV,ROLLINS SCH PUBL HLTH,WOMENS & CHILDRENS CTR,1518 CLIFTON RD ATLANTA GA 30322
Titolo Testata:
European journal of epidemiology
fascicolo: 5, volume: 13, anno: 1997,
pagine: 591 - 609
SICI:
0393-2990(1997)13:5<591:CLAIVD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDREN; STRAINS; VIRUS; B/ANN-ARBOR/1/86; SCHOOLCHILDREN; RECOMBINANTS; STABILITY; EFFICACY;
Keywords:
INFLUENZA CONTROL; REVIEW ARTICLE; RUSSIA; VACCINES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.P. Kendal, "COLD-ADAPTED LIVE ATTENUATED INFLUENZA VACCINES DEVELOPED IN RUSSIA -CAN THEY CONTRIBUTE TO MEETING THE NEEDS FOR INFLUENZA CONTROL IN OTHER COUNTRIES", European journal of epidemiology, 13(5), 1997, pp. 591-609

Abstract

It is now more than 30 years since the first cold-adapted influenza viruses were developed in Russia as potential live, attenuated vaccines. In the past 15-20 years considerable experience has been gained fromRussian and joint Russian-US laboratory and clinical studies with type A monovalent and bivalent vaccines prepared with genetic reassortantviruses derived from one of these cold-adapted viruses in particular,A/Leningrad/134/57. More recent experiences include use of trivalent cold-adapted vaccines with a type B component. The overall high level of safety of individual and combined vaccines in pre-school and school-aged children, with illness reductions in open field trials equivalent to that seen with inactivated vaccines, is such as to suggest that practical measures might now be justified to facilitate expansion of the use of these vaccines to other countries. It is proposed that further experimentation with the Russian cold-adapted live attenuated vaccines should be focused on issues that will relate to the public health perspective, i.e. selection of the single best candidiate type A and B vaccines for intense study using as criteria their potential for meeting licensing requirements outside Russia, and documenting the clinicalprotective efficacy of a single vaccine dose compared to two doses asstudied until now. Resolution of these issues is important to ensure that costs for future live vaccine production, control, and utilization will be kept at lowest levels so that expanded use of live vaccines will have maximum cost-benefit and affordability. To guide those interested in these issues, examples are given of populations for whom a licensed live cold-adapted vaccine might be considered, together with indications of extra data needed to fully validate each suggested use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:07:47