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Titolo:
PREVALENCE OF HEPATITIS-C VIRUS-INFECTION IN NANJING, SOUTHERN CHINA
Autore:
SUZUKI K; MIZOKAMI M; CAO K; WU XS; WU RR; HATA A; SASAKI M; FANG ZX; ZHANG LY; LAU JYN; IINO S;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT INTERNAL MED 2,1-1 KAWASUMI NAGOYA AICHI 467 JAPAN NAGOYA CITY UNIV,SCH MED,DEPT MED 2 NAGOYA AICHI 467 JAPAN
Titolo Testata:
European journal of epidemiology
fascicolo: 5, volume: 13, anno: 1997,
pagine: 511 - 515
SICI:
0393-2990(1997)13:5<511:POHVIN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-SEQUENCE; MOLECULAR-CLONING; JAPANESE PATIENTS; GENOME; SEROEPIDEMIOLOGY; ORGANIZATION; CARRIERS; REGIONS; STRAIN; HCV;
Keywords:
CHINA; GENOTYPE; HEPATITIS C VIRUS; PHYLOGENETIC TREE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Suzuki et al., "PREVALENCE OF HEPATITIS-C VIRUS-INFECTION IN NANJING, SOUTHERN CHINA", European journal of epidemiology, 13(5), 1997, pp. 511-515

Abstract

There is little information on the prevalence of hepatitis C virus (HCV) infection in China. The prevalence of HCV infection was determinedin 998 subjects (398 with liver disease and 600 without) in the city of Nanjing in southern China. Subjects were tested for anti-HCV antibodies by a second generation assay, We also determined serological HCV genotypes and HCV RNA sequences. Among the 600 subjects without liver disease, 3 (0.5%) were seroreactive for anti-HCV, All were less than 12 years of age and had a history of transfusion. Of the 398 liver disease patients, 20 (5.0%) were seroreactive for anti-HCV. Of 16 patientsin whom serological HCV genotype was determined, 10 (62.5%) were infected with HCV type 1, 5 (31.3%) with type 2 and 1 (6.3%) undetermined. HCV genomes sequenced from 2 patients belonged to genotype 2 and wereclosely related to strains in Beijing and Japan by molecular evolutionary analysis. These results suggest that HCV infection is rare and not a major cause of liver disease in southern China.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:13:58