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Titolo:
Use of non-heart-beating donors in renal transplantation
Autore:
Kimber, RM; Metcalfe, MS; White, SA; Nicholson, ML;
Indirizzi:
Univ Leicester, Leicester Gen Hosp, Dept Surg, Leicester LE5 4PW, Leics, England Univ Leicester Leicester Leics England LE5 4PW er LE5 4PW, Leics, England
Titolo Testata:
POSTGRADUATE MEDICAL JOURNAL
fascicolo: 913, volume: 77, anno: 2001,
pagine: 681 - 685
SICI:
0032-5473(200111)77:913<681:UONDIR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACHINE PERFUSION PRESERVATION; ASYSTOLIC KIDNEY DONORS; WARM ISCHEMIA; GRAFT FUNCTION; EXPERIENCE;
Keywords:
non-heart-beating donors; renal transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kimber, RM Univ Leicester, Leicester Gen Hosp, Dept Surg, Gwendolen Rd, Leicester LE54PW, Leics, England Univ Leicester Gwendolen Rd Leicester Leics England LE5 4PW and
Citazione:
R.M. Kimber et al., "Use of non-heart-beating donors in renal transplantation", POSTG MED J, 77(913), 2001, pp. 681-685

Abstract

The rate of renal transplantation has plateaued and is now limited by the number of donor organs available. In the past all donor kidneys came from living donors or controlled non-heart beating donors. It was not until the introduction of brainstem death criteria that cadaveric heart beating donorsbecame the main source. Recently, there has been renewed interest in non-heart beating donors, who have already suffered cardiorespiratory arrest. Kidneys from these donors have a unique set of problems associated with increased duration of warm ischaemia. To minimise this, the kidneys are cooled in situ using an intra-aortic balloon catheter and are perfused with cold hyperosmolar citrate. Retrieval can then proceed in the normal fashion. Despite a higher level of delayed graft function, the results from non-heart beating renal transplantation are good, with long term function comparable to cadaveric organs. If used safely, they enable significant expansion of the donor pool. Techniques in the future, such as machine perfusion preservation, may further improve the results from non-heart beating programmes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:34:47