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Titolo:
Developmental genetics evidence for a monophyletic origin of the bilaterian brain
Autore:
Reichert, H; Simeone, A;
Indirizzi:
Univ Basel, Inst Zool, Biozentrum Pharmazentrum, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 zentrum, CH-4056 Basel, Switzerland Univ London Kings Coll, MRC, Ctr Dev Neurobiol, London SE1 9RT, England Univ London Kings Coll London England SE1 9RT l, London SE1 9RT, England
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1414, volume: 356, anno: 2001,
pagine: 1533 - 1544
SICI:
0962-8436(20011029)356:1414<1533:DGEFAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE CORD DEVELOPMENT; HUMAN OTX GENES; HOMEOBOX GENE; EMBRYONIC BRAIN; HALOCYNTHIA-RORETZI; EARLY NEUROGENESIS; ANIMAL PHYLOGENY; DROSOPHILA BRAIN; MAMMALIAN BRAIN; COLUMN IDENTITY;
Keywords:
Hox genes; Otx; brain development; brain evolution; Drosophila; Urbilateria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Reichert, H Univ Basel, Inst Zool, Biozentrum Pharmazentrum, Klingelbergstr 50, CH-4056 Basel, Switzerland Univ Basel Klingelbergstr 50 Basel Switzerland CH-4056 erland
Citazione:
H. Reichert e A. Simeone, "Developmental genetics evidence for a monophyletic origin of the bilaterian brain", PHI T ROY B, 356(1414), 2001, pp. 1533-1544

Abstract

The widely held notion of an independent evolutionary origin of invertebrate and vertebrate brains is based on classical phylogenetic, neuroanatomical and embryological data. The interpretation of these data in favour of a polyphyletic origin of animals brains is currently being challenged by threefundamental findings that derive from comparative molecular, genetic and developmental analyses. First, modern molecular systematics indicates that none of the extant animals correspond to evolutionary intermediates between the protostomes and the deuterostomes, thus making it impossible to deduce tile morphological organization of the ancestral bilaterian or its brain from living species. Second, recent molecular genetic evidence for the body axis inversion hypothesis now supports the idea that the basic body plan of vertebrates and invertebrates is similar but inverted, suggesting that the ventral nerve chord of protostome invertebrates is homologous to the dorsalnerve cord of deuterostome chordates. Third, a developmental genetic analysis of the molecular control elements involved in early embryonic brain patterning is uncovering the existence of structurally and functionally homologous genes that have comparable and interchangeable functions in key aspects of brain development in invertebrate and vertebrate model systems. All three of these findings are compatible with the hypothesis of a monophyletic origin of the bilaterian brain. Here we review these findings and consider their significance and implications for current thinking on the evolutionary origin of bilaterian brains. We also preview the impact of comparative functional genomic analyses on our understanding of brain evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:34:46