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Titolo:
Persistent adenoviral infection and chronic obstructive bronchitis in children: Is there a link?
Autore:
Pichler, M; Herrmann, G; Schmidt, H; Ahrens, P; Zielen, S;
Indirizzi:
Univ Bonn, Kinderklin, D-53113 Bonn, Germany Univ Bonn Bonn Germany D-53113 v Bonn, Kinderklin, D-53113 Bonn, Germany Univ Frankfurt, Dept Pediat, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 ediat, D-6000 Frankfurt, Germany Univ Frankfurt, Dept Radiol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 adiol, D-6000 Frankfurt, Germany Univ Frankfurt, Dept Pathol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 athol, D-6000 Frankfurt, Germany
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 5, volume: 32, anno: 2001,
pagine: 367 - 371
SICI:
8755-6863(200111)32:5<367:PAIACO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; POLYMERASE CHAIN-REACTION; RAPID DETECTION; DNA-SEQUENCES; BRONCHIOLITIS; PROTEINS; CELLS;
Keywords:
bronchitis; adenovirus; bronchiolitis; wheezing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Zielen, S Univ Bonn, Kinderklin, Adenauerallee 119, D-53113 Bonn, Germany Univ Bonn Adenauerallee 119 Bonn Germany D-53113 Bonn, Germany
Citazione:
M. Pichler et al., "Persistent adenoviral infection and chronic obstructive bronchitis in children: Is there a link?", PEDIAT PULM, 32(5), 2001, pp. 367-371

Abstract

Chronic obstructive bronchitis with inadequate response to inhaled steroidand bronchodilator therapy is a rather rare disorder in children. Persistence of an adenoviral infection has been described as a possible cause of unremitting airway obstruction. We studied a group of 11 children with the clinical feature of chronic bronchial obstruction. A high-resolution computedtomography (HR-CT) scan was performed and typically showed hyperinflation and ground-glasslike opacities. All children underwent either bronchoscopictransbronchial or open lung biopsy. Biopsy specimens were stained with monoclonal antibodies detecting adenoviral antigen and analyzed by light-microscopy. Bronchoalveolar lavage (BAL) fluid was cultured for adenovirus, and antigen detection tests were performed. While some children had a history of proven adenoviral infection at the onset of their disease, in none of thecases could a persistence of adenovirus be shown. We conclude that adenoviral infection might act as a starter of chronic obstructive bronchitis in children, but that pathogenetic mechanisms other than persistent infection must be responsible for the chronicity of the disease. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:50:24