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Titolo:
Differential effects of sex steroids on T and B cells: Modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels
Autore:
McMurray, RW; Suwannaroj, S; Ndebele, K; Jenkins, JK;
Indirizzi:
Univ Mississippi, Dept Med, Div Rheumatol Mol Immunol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Mol Immunol, Jackson, MS 39216 USA GV Sonny Montgomery VA Hosp, Dept Med, Div Rheumatol, Jackson, MS USA GV Sonny Montgomery VA Hosp Jackson MS USA iv Rheumatol, Jackson, MS USA
Titolo Testata:
PATHOBIOLOGY
fascicolo: 1, volume: 69, anno: 2001,
pagine: 44 - 58
SICI:
1015-2008(2001)69:1<44:DEOSSO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; NF-KAPPA-B; ESTROGEN-RECEPTOR; GENE-EXPRESSION; GLUCOCORTICOID RECEPTOR; THYMOCYTE APOPTOSIS; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; C-JUN; PROGESTERONE;
Keywords:
steroid hormones; T lymphocytes; B lymphocytes; cell cycle; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: McMurray, RW Univ Mississippi, Med Ctr, Div Rheumatol & Mol Immunol, L525 Clin Sci Bldg,2500 N State St, Jackson, MS 39216 USA Univ Mississippi L525 Clin Sci Bldg,2500 N State St Jackson MS USA 39216
Citazione:
R.W. McMurray et al., "Differential effects of sex steroids on T and B cells: Modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels", PATHOBIOLOG, 69(1), 2001, pp. 44-58

Abstract

Sex steroids have dramatic and differential effects on classic endocrine organ proliferation and apoptosis. In this investigation we sought to delineate similar effects of sex steroids on proliferation, cell cycle phase and apoptosis in lymphocyte cell lines as models for T and B cells. Estrogen and testosterone inhibited T cell line proliferation, induced accumulation ofcells in S/G(2)M phases of the cell cycle, and increased apoptosis in a concentration-and time-dependent manner. There was a more modest effect of estrogen and testosterone on cell cycling and apoptosis in B lymphocyte cell lines, suggesting that estrogen and testosterone are inhibitory to T but not B cell lines. In comparison, progesterone induced cytostasis and modestlyincreased apoptosis in both T and B cell lines. Estrogen and testosterone were not antagonistic or synergistic to each other in their effects on cellcycle phase distribution, and only minimally synergistic for apoptosis. Incontrast, progesterone antagonized cell cycle and apoptotic effects of estrogen in T cells. Estrogen-induced cell cycle and apoptotic effects in T cell lines were associated with suppression of bcl-2 protein levels, which were unaffected in Raji B cells. Progesterone also antagonized the estrogen-induced changes in T cell bcl-2 protein levels. These results suggest that there may be significant and differential sex steroid effects on T and B lymphocytes that may be important to sexual dichotomies in immune and autoimmune responses. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 22/01/20 alle ore 09:52:48