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Titolo:
Long-term effect and tolerance of talc slurry for control of malignant pleural effusions
Autore:
Prevost, A; Costa, B; Elamarti, R; Nazeyrollas, P; Mallet, F; Yazbek, G; Cauchois, A;
Indirizzi:
Inst Jean Godinoi, Serv Chirurg, Ctr Reg Lutte Canc, F-51056 Reims, FranceInst Jean Godinoi Reims France F-51056 Lutte Canc, F-51056 Reims, France Fac Med, Lab Pharmacol Med, F-51100 Reims, France Fac Med Reims France F-51100 d, Lab Pharmacol Med, F-51100 Reims, France
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 1327 - 1331
SICI:
1021-335X(200111/12)8:6<1327:LEATOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED TRIAL; PLEURODESIS; BLEOMYCIN; INSUFFLATION; TETRACYCLINE; INSTILLATION; POUDRAGE; EFFICACY;
Keywords:
malignant pleural effusion; pleurodesis; slurry talc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Prevost, A Inst Jean Godinoi, Serv Chirurg, Ctr Reg Lutte Canc, 1 Ave Gen Koenig, F-51056 Reims, France Inst Jean Godinoi 1 Ave Gen Koenig Reims France F-51056 France
Citazione:
A. Prevost et al., "Long-term effect and tolerance of talc slurry for control of malignant pleural effusions", ONCOL REP, 8(6), 2001, pp. 1327-1331

Abstract

Drainage of malignant pleural effusions (MPE) by thoracocenthesis and subsequent pleurodesis is an established means of symptomatic relief in terminally-ill patients, but the optimal therapy remains unclear. Among many sclerosing agent, talc is the most widely used, but its intrapleural administration and dosage have not been clearly determined. To assess the efficacy of using talc slurry with high dose (8 g) as a sclerosing agent instilled intothe pleural space at the patient bedside, we carried out a study in 31 patients suffering from symptomatic MPE, followed until death or up to 1 year with radiographs. Patients were evaluated for immediate tolerance (31 patients), and for efficacy and longterm tolerance (27 patients) of the talc therapy. We have shown, that pleurodesis was satisfactory in 22/27 patients (81.4%). This result appeared comparable with other series. Moreover, we observed a long-lasting efficacy: within 6 months and within 12 months after talc instillations, 20/20 patients and 9/9 patients respectively were symphysed with efficacy. Complications related to talc (8 g) were rare and moderate (pain, fever). Taking into account some technical aspects of talc instillation for good performance of the therapy, we recommend this method as the optimal route of administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:45:43