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Titolo:
Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells
Autore:
Chang, HC; Weng, CF;
Indirizzi:
Kaohsiung Med Univ, Dept Physiol, Kaohsiung 807, Taiwan Kaohsiung Med Univ Kaohsiung Taiwan 807 t Physiol, Kaohsiung 807, Taiwan Natl Donghwa Univ, Inst Biotechnol, Hualien, Taiwan Natl Donghwa Univ Hualien Taiwan Univ, Inst Biotechnol, Hualien, Taiwan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 1321 - 1325
SICI:
1021-335X(200111/12)8:6<1321:CLACCI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; INCREASED EXPRESSION; GROWTH-INHIBITION; TRANSFORMED-CELLS; EPITHELIAL-CELLS; PROSTAGLANDIN; ADENOCARCINOMAS; SYNTHASE; PROTEIN; LINES;
Keywords:
cyclooxygenase-2; NS398; caspase-3; poly(ADP-ribose) polymerase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, HC Kaohsiung Med Univ, Dept Physiol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan Kaohsiung Med Univ 100 Shih Chuan 1st Rd Kaohsiung Taiwan 807 n
Citazione:
H.C. Chang e C.F. Weng, "Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells", ONCOL REP, 8(6), 2001, pp. 1321-1325

Abstract

Cyclooxygenases (COXs) catalyze the synthesis of prostaglandins (PGs) fromarachidonic acid. Overexpression of COX-2 is frequently found in human cancers and is suggested to play an important role in tumorigenesis. Recent studies indicated that COX-2 inhibitors exert potent anti-cancer effects on anumber of cancers. Interestingly, some COX-2 inhibitors potently induce apoptosis, while other COX-2 inhibitors primarily induce growth inhibition. Therefore, there is a variability in the effects that different COX-2 inhibitors have on cancer cells. In this study, we demonstrated that induction ofapoptosis of high COX-2-expressing A549 lung cancer cells by a specific COX-2 inhibitor NS398 was observed in cells cultured under serum-free condition. However, this drug induced GI growth arrest rather than apoptosis in A549 cells maintained in 10% serum medium. Conversely, low COX-2-expressing H226 lung cancer cells were resistant to NS398-induced apoptosis under both serum-free and serum-containing conditions. Moreover, our results showed that NS398-induced apoptosis is associated with activation of caspase-3, a cysteine protease that plays a crucial role in the execution phase of apoptosis. These results suggest that the cytotoxic effect of COX-2 inhibitors on cancer cells may be influenced by extracellular environments and the anti-cancer action of these inhibitors in vivo needs careful evaluation. Additionally, a correlation between the level of COX-2 expression and the extent ofapoptosis induced by COX-2 inhibitors was found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:32:25