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Titolo:
Fhit protein expression in human gastric cancer and related precancerous lesions
Autore:
Caselli, M; Marchisio, M; Gaudio, M; Saragoni, L; Lanza, G; Alvisi, V; Bertagnolo, V; Concu, M; Capitani, S; Caramelli, E;
Indirizzi:
Univ Ferrara, Human Anat Branch, Dept Morphol & Embryol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 hol & Embryol, I-44100 Ferrara, Italy Univ Ferrara, Inst Internal Med 1, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 nternal Med 1, I-44100 Ferrara, Italy Morgagni Pierantoni Hosp, Dept Pathol, Forli, Italy Morgagni Pierantoni Hosp Forli Italy ni Hosp, Dept Pathol, Forli, Italy Univ Ferrara, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 Diagnost Med, I-44100 Ferrara, Italy Univ Bologna, Inst Histol & Gen Embryol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 & Gen Embryol, I-40126 Bologna, Italy
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 1233 - 1237
SICI:
1021-335X(200111/12)8:6<1233:FPEIHG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; HELICOBACTER-PYLORI INFECTION; TUMOR-SUPPRESSOR GENE; LUNG-CANCER; PREMALIGNANT LESIONS; BRONCHIAL LESIONS; FRAGILE REGION; BREAST-CANCER; 3P14.2; FRA3B;
Keywords:
gastric carcinogenesis; FHIT; RT-PCR; Fhit protein immunostaining;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Capitani, S Univ Ferrara, Human Anat Branch, Dept Morphol & Embryol, Via Fossato di Mortara 66, I-44100 Ferrara, Italy Univ Ferrara Via Fossato di Mortara 66 Ferrara Italy I-44100
Citazione:
M. Caselli et al., "Fhit protein expression in human gastric cancer and related precancerous lesions", ONCOL REP, 8(6), 2001, pp. 1233-1237

Abstract

The FHIT gene is altered in several types of tumors and abnormal expression of Fhit protein have also been reported in some preneoplastic lesions. Wehave determined the Fhit expression on histological samples of 26 patientsaffected by preneoplastic lesions who developed a gastric cancer within 2 years. The expression of the Fhit protein was always present in all preneoplastic lesions, while the Fhit protein immunostaining was distributed unevenly in 10 cases and completely lost in 6. The complete loss of Fhit expression only in areas of neoplastic low differentiation suggests that FHIT genetakes part in late gastric carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:05:12