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Titolo:
Up-regulation of neuroendocrine differentiation in prostate cancer after androgen deprivation therapy, degree and androgen independence
Autore:
Ito, T; Yamamoto, S; Ohno, Y; Namiki, K; Aizawa, T; Akiyama, A; Tachibana, M;
Indirizzi:
Tokyo Med Univ, Dept Urol, Shinjuku Ku, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 ol, Shinjuku Ku, Tokyo 1600023, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 1221 - 1224
SICI:
1021-335X(200111/12)8:6<1221:UONDIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOGRANIN-A; HORMONAL TREATMENT; GROWTH-FACTORS; HUMAN BENIGN; CARCINOMA; CELLS; PROGNOSIS; ADENOCARCINOMA; PEPTIDE; MARKER;
Keywords:
androgen independence; chromogranin A; hormone refractory; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, T Tokyo Med Univ, Dept Urol, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan Tokyo Med Univ 6-7-1 Nishishinjuku Tokyo Japan 1600023 0023, Japan
Citazione:
T. Ito et al., "Up-regulation of neuroendocrine differentiation in prostate cancer after androgen deprivation therapy, degree and androgen independence", ONCOL REP, 8(6), 2001, pp. 1221-1224

Abstract

The up-regulation of neuroendocrine (NE) differentiation after hormonal therapy, as well as the relationship between the degree of NE differentiationand androgen independence was investigated. One hundred and thirty-seven whole prostate specimens that were derived from surgery and autopsy (group A: no hormonal therapy, 44 patients; group B: with hormonal therapy less than 12 months, 25 patients; group C: with hormonal therapy more than 13 months, 68 patients) were studied. Neuroendocrine differentiation was evaluated by immunostaining with chromogranin A. The degree of NE differentiation wasevaluated by the percentage area of positive NE cell expression (grade 0, negative; grade 1, 1-33%; grade 2, 34-66%; grade 3, 67-100%). The degree ofNE differentiation was compared in androgen-independent and -dependent tumors in group C. Neuroendocrine differentiation was expressed as 31.8% in group A, 44% in group B and 70.5% in group C (p <0.001, Chi-squared test). Group C included 20 androgen-independent cases in which 3 cases were grade 0,2 were grade 1, 6 were grade 2 and 9 were grade 3. Conversely, for androgen-dependent cases, there were 16, 16, 11 and 5 cases, respectively. Neuroendocrine cells, whether positive or not, alone was not significantly different (p=0.124, Chi-squared test); however, the percentage area of positive NEcell expression was significantly different between the androgen-independent and -dependent tumors (p=0.0044, Chi-squared test). Hormonal therapy mayplay an important role in the up-regulation of NE differentiation. As wellas NE cell expression, whether positive or not, the degree of expression should also be observed to evaluate a poor prognosis, tumor progression and androgen independence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:03:33