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Titolo:
PML interaction with p53 and its role in apoptosis and replicative senescence
Autore:
Pearson, M; Pelicci, PG;
Indirizzi:
European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol Milan Italy I-20141 Expt Oncol, I-20141 Milan, Italy
Titolo Testata:
ONCOGENE
fascicolo: 49, volume: 20, anno: 2001,
pagine: 7250 - 7256
SICI:
0950-9232(20011029)20:49<7250:PIWPAI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROMYELOCYTIC LEUKEMIA PROTEIN; TELOMERASE CATALYTIC SUBUNIT; CREB-BINDING-PROTEIN; NUCLEAR-BODIES; ONCOGENIC RAS; DNA-DAMAGE; PREMATURE SENESCENCE; CELLULAR SENESCENCE; TUMOR SUPPRESSION; HUMAN FIBROBLASTS;
Keywords:
PML; p53; apoptosis; senescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Pearson, M European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol Milan Italy I-20141 I-20141 Milan, Italy
Citazione:
M. Pearson e P.G. Pelicci, "PML interaction with p53 and its role in apoptosis and replicative senescence", ONCOGENE, 20(49), 2001, pp. 7250-7256

Abstract

A network of control pathways has been characterized that arrest growth orinduce apoptosis in response to potentially tumorogenic events such as genotoxic stress or oncogene expression. Ablation, or functional disruption, of these pathways is frequently observed during multistep carcinogenesis. Analysis of those genes most commonly compromized in tumours has led to the identification of the transcription factor p53 and the E2F binding protein Retinoblastoma (Rb), as key regulators of these processes. This review discusses recent data, demonstrating that the Promyelocytic Leukemia (PML) protein can physically and functionally interact with both p53 and Rb, suggesting that PML may be a novel regulator of these pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:54:20