Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management
Autore:
Cassinat, B; Chomienne, C;
Indirizzi:
Hop St Louis, Inst Hematol, Lab Biol Cellulaire Hematopoiet, INSERM E 00 03, F-75010 Paris, France Hop St Louis Paris France F-75010 INSERM E 00 03, F-75010 Paris, France
Titolo Testata:
ONCOGENE
fascicolo: 49, volume: 20, anno: 2001,
pagine: 7154 - 7160
SICI:
0950-9232(20011029)20:49<7154:BFOPAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; TRANS-RETINOIC ACID; PML-RAR-ALPHA; INDUCED GRANULOCYTIC DIFFERENTIATION; COLONY-STIMULATING FACTOR; HISTONE DEACETYLASE; MYELOID-LEUKEMIA; RECEPTOR-ALPHA; CELLS; GENE;
Keywords:
APL blasts; differentiation; granulopoiesis; retinoids; RARa gene rearrangements;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Chomienne, C Hop St Louis, Inst Hematol, Lab Biol Cellulaire Hematopoiet, INSERM E 00 03, 1 Ave Claude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 nce
Citazione:
B. Cassinat e C. Chomienne, "Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management", ONCOGENE, 20(49), 2001, pp. 7154-7160

Abstract

In recent years, discovery of the in vitro and in giro differentiation of APL blasts by all-trans retinoic acid (ATRA) has modified the therapeutic approach of APL and lead to important advances in understanding the biology of APL. Since it became apparent that differentiation therapy of APL with ATRA was indeed a true model of targetted therapy, evidencing the molecular targets of retinoic acid efficacy became crucial. These molecular targets are closely related to the biological features of APL cells, some of which are well-known and have contributed to the morphological and cytogenetic definition of the leukemia, others have just been defined or re-discovered in the light of a better understanding of molecular controls of cell growth and differentiation. The aims of characterizing the biological features of APL cells should allow a better management of APL therapy and the identification of potential markers for differentiation therapies in other leukemias or solid tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:50:15