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Titolo:
p73 overexpression increases VEGF and reduces thrombospondin-1 production:implications for tumor angiogenesis
Autore:
Vikhanskaya, F; Bani, MR; Borsotti, P; Ghilardi, C; Ceruti, R; Ghisleni, G; Marabese, M; Giavazzi, R; Broggini, M; Taraboletti, G;
Indirizzi:
Mario Negri Inst Pharmacol Res, Dept Oncol, I-24125 Bergamo, Italy Mario Negri Inst Pharmacol Res Bergamo Italy I-24125 4125 Bergamo, Italy Univ Milan, Ist Anat Patol Vet & Patol Aviare, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Vet & Patol Aviare, I-20133 Milan, Italy Mario Negri Inst Pharmacol Res, Dept Oncol, I-24125 Bergamo, Italy Mario Negri Inst Pharmacol Res Bergamo Italy I-24125 4125 Bergamo, Italy
Titolo Testata:
ONCOGENE
fascicolo: 50, volume: 20, anno: 2001,
pagine: 7293 - 7300
SICI:
0950-9232(20011101)20:50<7293:POIVAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BLADDER-CANCER; GROWTH-FACTOR GENE; CELL-LINES; MALIGNANT PROGRESSION; ENDOTHELIAL-CELLS; SUPPRESSOR GENE; C-JUN; EXPRESSION; P53; TRANSCRIPTION;
Keywords:
p73; angiogenesis; thrombospondin-1; VEGF; ovarian carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Taraboletti, G Mario Negri Inst Pharmacol Res, Dept Oncol, Via Gavazzeni 11, I-24125 Bergamo, Italy Mario Negri Inst Pharmacol Res Via Gavazzeni 11 Bergamo Italy I-24125
Citazione:
F. Vikhanskaya et al., "p73 overexpression increases VEGF and reduces thrombospondin-1 production:implications for tumor angiogenesis", ONCOGENE, 20(50), 2001, pp. 7293-7300

Abstract

Tumor neovascularization is controlled by a balance between positive and negative effectors, whose production can be regulated by oncogenes and tumorsuppressor genes. The aim of this study was to investigate whether the angiogenic potential of tumors could also be controlled by p73, a gene homologous to the tumor suppressor p53, whose involvement in tumor angiogenesis isknown. We have studied the production of proangiogenic (VEGF, FGF-2, PIGF and PDGF) and antiangiogenic (TSP-1) factors in two p73 overexpressing clones obtained from the human ovarian carcinoma cells A2780. TSP-1 was downregulated in both clones compared to mock transfected cells, both at mRNA bindprotein level. Conversely, both clones showed an increased production of VEGF mRNA and protein. For both TSP-1 and VEGF, regulation of expression waspartially due to modulation of the promoter activity, and was dependent onp53 status. Production of the other angiogenic factors FGF-2, PIGF and PDGF-B was also increased in p73 overexpressing clones. The two clones were more angiogenic than parental cells, as shown in vitro by their increased chemotactic activity for endothelial cells, and in vivo by the generation of more vascularized tumors. These findings suggest a potential role of p73 in tumor angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:42:49