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Titolo:
Menstrual reduction with extended use of combination oral contraceptive pills: Randomized controlled trial
Autore:
Miller, L; Notter, KM;
Indirizzi:
Univ Washington, Sch Med, Dept Obstet & Gynecol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 tet & Gynecol, Seattle, WA 98195 USA
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 5, volume: 98, anno: 2001,
parte:, 1
pagine: 771 - 778
SICI:
0029-7844(200111)98:5<771:MRWEUO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE WITHDRAWAL SYMPTOMS; DESOGESTREL; REGIMEN; CYCLE; POSTPONEMENT; FREQUENCY; SYSTEM; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, L 325 9th Ave, Seattle, WA 98104 USA 325 9th Ave Seattle WA USA 98104 9th Ave, Seattle, WA 98104 USA
Citazione:
L. Miller e K.M. Notter, "Menstrual reduction with extended use of combination oral contraceptive pills: Randomized controlled trial", OBSTET GYN, 98(5), 2001, pp. 771-778

Abstract

OBJECTIVE: To compare a traditional 28-day cycle to an extended 49-day cycle of the 30 mug ethinyl estradiol (E2)/300 mug norgestrel monophasic birthcontrol pill regimen. METHODS: Ninety subjects randomized to either 28-day cycles with 21 activepills or 49-day cycles with 42 active pills for a prospective open label trial over four 84-day reference periods or trimesters. Bleeding, pill taking, and symptom diaries were completed. The sample size with 80% power to detect a 40% reduction in bleeding days required 24 subjects in each arm. RESULTS: Of the 90 women, 24 subjects (54.5%) on the 28-day cycle and 29 (63%) on the 49-day cycle completed the entire study (P = .41). There were no statistically significant differences between the two groups in demographics or continuation rates. There was a significant reduction in bleeding days in the experimental arm beginning in the first trimester (28-day = 10.9,49-day = 6.4 mean days of bleeding, P < .001) and continuing to the fourthtrimester (28-day = 11.3, 49-day = 5.8 mean days, P = .005). The number ofspotting days was similar between both schedules in the first trimester (28-day = 4.8, 49-day = 3.7 mean days, P = .24) and continued into the fourthtrimester (28-day = 3.4, 49-day = 2.9 mean days, P = .30). Annual expenditure for hygiene products was significantly less for extended use subjects (28-day $41.45, 49-day = $17.54 spent, P < .001). CONCLUSION: Extension of the 28-day oral contraceptive (OC) cycle to a 49-day cycle resulted in fewer bleeding days and no increase in mean spotting days or bleeding episodes. (Obstet Gynecol 2001;98:771-8. (C) 2001 by the American College of Obstetricians and Gynecologists).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:26:16