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Titolo:
Synthesis and biological evaluation of some 4-substituted 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4&5)-ylmethyl]1H-pyrazolo-[3,4-d]pyrimidines
Autore:
Moukha-Chafiq, O; Taha, ML; Lazrek, HB; Vasseur, JJ; Pannecouque, C; Witvrouw, M; De Clercq, E;
Indirizzi:
Fac Sci, Chim Bioorgan Lab, Agadir, Morocco Fac Sci Agadir MoroccoFac Sci, Chim Bioorgan Lab, Agadir, Morocco UST Montpellier 2, Lab Chim Organ Biomol Synthese, Montpellier, France USTMontpellier 2 Montpellier France omol Synthese, Montpellier, France Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium a Inst Med Res, Louvain, Belgium
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 10-11, volume: 20, anno: 2001,
pagine: 1811 - 1821
SICI:
1525-7770(2001)20:10-11<1811:SABEOS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANALOGS; ACYCLONUCLEOSIDES; HBG; 9-(4-HYDROXYBUTYL)GUANINE; NUCLEOSIDES; ASSAY; ACV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Taha, ML Fac Sci, Chim Bioorgan Lab, BP 28-S, Agadir, Morocco Fac Sci BP 28-S Agadir Morocco an Lab, BP 28-S, Agadir, Morocco
Citazione:
O. Moukha-Chafiq et al., "Synthesis and biological evaluation of some 4-substituted 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4&5)-ylmethyl]1H-pyrazolo-[3,4-d]pyrimidines", NUCLEOS NUC, 20(10-11), 2001, pp. 1811-1821

Abstract

The synthesis of 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4 and 5)-ylmethyl]1H-pyrazolo[3,4-d]pyrimidines 11a,b, 12a,b and 13-17 as carboacyclic nucleosides is described. The compounds 8a,b were condensed, separately, with compound 7 via 1,3-dipolar cycloaddition reaction to afford, after separation and deprotection, 1,4-regioisomers 11a,b and 1,5-regioisomers 12a,b. The deprotected carboacyclic nucleosides 11a served as precursor for the preparation of 4-amino 13, 4-methylamino 14, 4-benzylamino 15, 4-methoxy 16 and 4-hydroxy 17 analogues. All deprotected carboacyclic nucleosides were evaluated for their inhibitory effects against the replication of HIV-1(IIIB), HIV-2(ROD), various DNA viruses, a variety of tumor-cell lines and tuberculosis. No marked biological activity was found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:01:56