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Titolo:
Evaluation of stannous oxidation in the preparation of ultrahigh-purity Tc-99m(V)-DMSA
Autore:
Kumar, V;
Indirizzi:
Westmead Hosp, Dept Nucl Med & Ultrasound, Sydney, NSW 2145, Australia Westmead Hosp Sydney NSW Australia 2145 ound, Sydney, NSW 2145, Australia
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 11, volume: 22, anno: 2001,
pagine: 1261 - 1266
SICI:
0143-3636(200111)22:11<1261:EOSOIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TC-99M DIMERCAPTOSUCCINIC ACID; MEDULLARY CARCINOMA; PENTAVALENT; DMSA; KIT;
Keywords:
technetium-99m dimercaptosuccinic acid; radiochemical purity; stannous oxidation; renal imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, V Westmead Hosp, Dept Nucl Med & Ultrasound, Sydney, NSW 2145, Australia Westmead Hosp Sydney NSW Australia 2145 ney, NSW 2145, Australia
Citazione:
V. Kumar, "Evaluation of stannous oxidation in the preparation of ultrahigh-purity Tc-99m(V)-DMSA", NUCL MED C, 22(11), 2001, pp. 1261-1266

Abstract

It has been shown previously that renal kit, trivalent technetium-99m dimercaptosuccinic acid [Tc-99m(III)-DMSA], can be transformed into tumour imaging agent, pentavalent technetium-99m DMSA [Tc-99m(V)-DMSA], by adding sodium bicarbonate (NaHCO3) and subsequently bubbling with oxygen. However, thepurity of this pentavalent preparation was reported to be in the range 83-94% at best. In this study, the preparation of ultrahigh-purity Tc-99m(V)-DMSA is described, and the role of stannous oxidation in the conversion of Tc-99m(III)-DMSA to Tc-99m(V)-DMSA is evaluated in order to understand the underlying mechanism. The results show that controlled oxygen bubbling increases the Tc-99m(V)-DMSA levels, with a concomitant decrease in the Tc-99m(III)-DMSA levels, in a time-dependent pattern. The purity of the pentavalentDMSA is shown to be consistently very high (> 99%), as estimated by chromatography, and this correlates very well with the minimal or no renal uptakeof this compound in patient studies. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:58:50