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Titolo:
Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats
Autore:
You, ZD; Li, JH; Song, CY; Lu, CL; He, C;
Indirizzi:
Mil Med Coll 2, Dept Neurobiol, Shanghai 200433, Peoples R China Mil Med Coll 2 Shanghai Peoples R China 200433 i 200433, Peoples R China
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 41, anno: 2001,
pagine: 143 - 150
SICI:
0168-0102(200110)41:2<143:OMTIAO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROHYPOPHYSEAL PEPTIDES; METHADONE DEPENDENCE; OPIATE WITHDRAWAL; INTERFERON-ALPHA; MICE; VASOPRESSIN; TOLERANCE; BRAIN; ANTINOCICEPTION; RECEPTOR;
Keywords:
lithium; morphine tolerance; morphine dependence; analgesia; conditioned place preference; withdrawal syndrome; rats; oxytocin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: You, ZD Mil Med Coll 2, Dept Neurobiol, 800 Xiang Yin Rd, Shanghai 200433,PeoplesR China Mil Med Coll 2 800 Xiang Yin Rd Shanghai Peoples R China 200433 a
Citazione:
Z.D. You et al., "Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats", NEUROSCI RE, 41(2), 2001, pp. 143-150

Abstract

The role of central oxytocin in inhibitory action of lithium on the development of morphine dependence was behavioral investigated in rats. Acute lithium could enhance the morphine-induced analgesia in rats with or without chronic morphine treatment; this effect could be inhibited by intraventricular injection of oxytocin antagonist d (CH2)(5)-Tyr (Me)-[Orn(8)]-Vasotocin (OVT). Lithium could attenuate naloxone-precipitated withdrawal signs in morphine dependent rats. The reduction of the expression of naloxone-precipitated withdrawal signs by lithium was reversed by ICV of OVT. The lithium significantly inhibited the conditioned place preference (CPP) induced by morphine, which inhibitory action of lithium could also reverse by ICV injection of OVT. These results suggested that lithium might inhibit the physical dependence on morphine as well as psychological dependence in rats, and that this inhibitory effect of lithium on the development of morphine dependence might be associated with oxytocin systems in the central nervous system. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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Documento generato il 10/07/20 alle ore 17:30:50