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Titolo:
The effects of dopamine and its antagonists on directional delay-period activity of prefrontal neurons in monkeys during an oculomotor delayed-response task
Autore:
Sawaguchi, T;
Indirizzi:
Hokkaido Univ, Grad Sch Med, Neurobiol Lab, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 41, anno: 2001,
pagine: 115 - 128
SICI:
0168-0102(200110)41:2<115:TEODAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
REACTION-TIME TASK; WORKING-MEMORY; D-1 ANTAGONIST; D1 RECEPTORS; IN-VITRO; CORTEX; MODULATION; SCHIZOPHRENIA; NEUROLEPTICS; SCH-23390;
Keywords:
prefrontal cortex; dopamine; D1-receptor; memory field; working memory; iontophoresis; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sawaguchi, T Hokkaido Univ, Grad Sch Med, Neurobiol Lab, Kita Ku, N 15 W 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N 15 W 7 Sapporo Hokkaido Japan 0608638 , Japan
Citazione:
T. Sawaguchi, "The effects of dopamine and its antagonists on directional delay-period activity of prefrontal neurons in monkeys during an oculomotor delayed-response task", NEUROSCI RE, 41(2), 2001, pp. 115-128

Abstract

To examine the role of dopamine receptors in the memory field of neurons for visuospatial working memory in the prefrontal cortex (PFC), dopamine andits antagonists (SCH23390 for the D1-antagonist and sulpiride for the D2-antagonist) were applied iontophoretically to neurons of the dorsolateral PFC in monkeys that performed an oculomotor delayed-response task. In this task, the subject made a memory-guided saccade to a remembered target location that had been cued by a visuospatial stimulus (right, up, left, or down; 15 degrees in eccentricity) prior to a 4-s delay period. We focused here onPFC neurons that showed directional delay-period activity i.e., an increased activity during the delay period, the magnitude of which varied significantly with the target location. Iontophoretic application of SCH23390 (usually 50 nA) decreased or increased the activities of most of these neurons (n = 48/62, 77%) most neurons showed a decrease (n = 43/62, 69%). For the neurons affected by SCH23390, a directional index of directional delay-periodactivity was attenuated by SCH23390, whereas the preferred direction was not greatly affected. The decreasing effect of SCH23390 was dose-dependent; the extent of the decrease was less with a lower dose (20-nA current) than with the ordinary dose (50-nA current), although the effect of the lower dose of SCH23390 on delay-period activity was similar in nature to that of the ordinary dose of SCH23390. Furthermore, the application of dopamine itself augmented directional delay-period activity in most of the neurons tested(n = 12/16, 75%). Sulpiride did not have any significant effects in most of the neurons tested (n = 15/17). These results suggest that the activationof DI-dopamine receptors play a facilitating role in the memory field of PFC neurons for visuospatial working memory processes. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:27:25