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Titolo:
Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy
Autore:
Morris, HR; Schrag, A; Nath, U; Burn, D; Quinn, NP; Daniel, S; Wood, NW; Lees, AJ;
Indirizzi:
Univ London, Inst Neurol, Dept Clin Neurol, Parkinsons Dis Soc Brain Res Ctr, London WC1N 3BG, England Univ London London England WC1N 3BG in Res Ctr, London WC1N 3BG, England Univ London, Inst Neurol, Dept Clin Neurol, Neurogenet Sect, London WC1N 3BG, England Univ London London England WC1N 3BG genet Sect, London WC1N 3BG, England Univ Coll London, Reta Lila Weston Inst Neurol Sci, London W1P 6DB, England Univ Coll London London England W1P 6DB rol Sci, London W1P 6DB, England Univ London, Inst Neurol, Dept Clin Neurol, Movement Disorders Sect, London WC1N 3BG, England Univ London London England WC1N 3BG rders Sect, London WC1N 3BG, England Royal Victoria Infirm, Dept Neurol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 312, anno: 2001,
pagine: 118 - 120
SICI:
0304-3940(20011019)312:2<118:EOAATO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; E GENOTYPE; OF-ONSET; GENE; FAMILIES;
Keywords:
progressive supranuclear palsy; multiple system atrophy; Alzheimer's disease; ApoE epsilon 4 allele;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Lees, AJ Univ London, Inst Neurol, Dept Clin Neurol, Parkinsons Dis Soc Brain Res Ctr, Queen Sq, London WC1N 3BG, England Univ London Queen Sq London England WC1N 3BG n WC1N 3BG, England
Citazione:
H.R. Morris et al., "Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy", NEUROSCI L, 312(2), 2001, pp. 118-120

Abstract

In addition to allelic association between genetic polymorphisms and diseases, modulation of age of onset is a well recognised effect of disease susceptibility genes. The ApoE is an element of4 allele is associated with an earlier age of onset of sporadic and familial Alzheimer's disease. It has been suggested that the tau genotype influences the age of onset of progressive supranuclear palsy (PSP), a form of atypical parkinsonism caused by tau neurofibrillary tangle deposition. We have therefore analysed the relationship between tau and ApoE genotypes and the age of onset of PSP and another form of atypical parkinsonism, multiple system atrophy (MSA). We have not found any effect of possession of the tau H1 haplotype or the ApoE is an element of4 allele on the age of onset of MSA or PSP. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:04:11