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Titolo:
Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding
Autore:
Davidowa, H; Plagemann, A;
Indirizzi:
Humboldt Univ, Fac Med Charite, Johannes Mueller Inst Physiol, D-10117 Berlin, Germany Humboldt Univ Berlin Germany D-10117 st Physiol, D-10117 Berlin, Germany Humboldt Univ, Fac Med Charite, Inst Expt Endocrinol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 Endocrinol, D-10098 Berlin, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3201 - 3204
SICI:
0959-4965(20011029)12:15<3201:IBIOHV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAHYPOTHALAMIC HYPERINSULINISM; FOOD-INTAKE; BRAIN; OBESITY; EXPRESSION; RESPONSES; RECEPTORS; INFUSION; NPY;
Keywords:
brain slice; insulin; overweight; postnatal overnutrition; rat hypothalamus; single unit activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Davidowa, H Humboldt Univ, Fac Med Charite, Johannes Mueller Inst Physiol,Tucholskystr 2, D-10117 Berlin, Germany Humboldt Univ Tucholskystr 2 Berlin Germany D-10117 , Germany
Citazione:
H. Davidowa e A. Plagemann, "Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding", NEUROREPORT, 12(15), 2001, pp. 3201-3204

Abstract

Single unit activity was studied in brain slices of normal and overweight adolescent rats, the latter grown up until weaning in small litters of three pups per mother (SL). Significantly fewer neurons of the ventromedial hypothalamic nucleus (VMN) were activated by insulin in overweight SL rats than in normal (NL) rats (chi (2) p < 0.01). Although there is no significant difference between NL and SL rats in the number of VMN neurons responsive to insulin, the neurons differ in the type of reaction. In overweight SL rats neurons were mainly inhibited by insulin (Wilcoxon test p<0.0001, n=45). This altered response to the satiety signal insulin in postnatally over-nourished rats might contribute to their persisting hyperphagia and overweight. NeuroReport 12:3201-3204 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:50:39