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Titolo:
Increased synaptic plasticity in the surround of visual cortex lesions in rats
Autore:
Mittmann, T; Eysel, UT;
Indirizzi:
Ruhr Univ Bochum, Dept Neurophysiol, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 physiol, D-44780 Bochum, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3341 - 3347
SICI:
0959-4965(20011029)12:15<3341:ISPITS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NMDA RECEPTORS; NEOCORTEX; DEPRESSION; EXPRESSION; EXPERIENCE; SYNAPSES;
Keywords:
intracellular recordings; lesion; LTD; LTP; slices; synaptic plasticity; rat; reorganization; visual cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mittmann, T Ruhr Univ Bochum, Dept Neurophysiol, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 4780 Bochum, Germany
Citazione:
T. Mittmann e U.T. Eysel, "Increased synaptic plasticity in the surround of visual cortex lesions in rats", NEUROREPORT, 12(15), 2001, pp. 3341-3347

Abstract

Lesion-induced functional loss is reduced when new synaptic connections are established in the surround of a cortical lesion. For this, long-term synaptic plasticity can play a key role. We studied long-term potentiation (LTP) and long-term depression (LTD) in slices of rat visual cortex with smallcortical lesions. Surprisingly, the normal balance between LTP and LTD wassignificantly altered in the first week following cortical injury. Theta-burst induced LTP was increased, whereas LTD evoked by low frequency stimulation was not affected. The increased potentiation of subcortical inputs after cortical lesions opens a window for facilitated early functional reorganization by repetitive visual training. NeuroReport 12:3341-3347 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 07:03:52