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Titolo:
Is frontal lobe involved in the generation of auditory evoked P50?
Autore:
Weisser, R; Weisbrod, M; Roehrig, M; Rupp, A; Schroeder, J; Scherg, M;
Indirizzi:
Univ Heidelberg, Dept Psychiat, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Univ Heidelberg, Dept Neurol, Sect Biomagnetism, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3303 - 3307
SICI:
0959-4965(20011029)12:15<3303:IFLIIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTEX; SCHIZOPHRENIA; INHIBITION; POTENTIALS;
Keywords:
AEF; AEP; auditory cortex; EEG; frontal lobe; MEG; P30m; P50; sensory gating; spatio-temporal source analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Weisbrod, M Univ Heidelberg, Dept Psychiat, Voss Str 4, D-69115 Heidelberg, Germany Univ Heidelberg Voss Str 4 Heidelberg Germany D-69115 Germany
Citazione:
R. Weisser et al., "Is frontal lobe involved in the generation of auditory evoked P50?", NEUROREPORT, 12(15), 2001, pp. 3303-3307

Abstract

This study examined the functional substrate of P50 suppression. Auditory evoked potentials (AEPs) and magnetic fields (AEFs) were recorded from healthy subjects simultaneously and analyzed using spatio-temporal source analysis. The resulting equivalent dipole model for the AEP consisted of one source in the auditory cortex (AC) of each hemisphere and an radially orientedmedial frontal source, both with maximum AEP activity around 50 ms. The frontal source was functionally separated from the AC sources since it peakedsignificantly later and showed significantly larger P50 amplitude suppression. P30m showed neither suppression nor substantial frontal activity. In sum, this study relates P50 suppression to reduction of AC source activity and is the first to yield direct evidence for frontal involvement in P50 suppression. NeuroReport 12:3303-3307 (C) 2001 Lippincott Williams. & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 17:43:41