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Titolo:
Bcl-2 is not required in retinal ganglion cells surviving optic nerve axotomy
Autore:
Dietz, GPH; Kilic, E; Bahr, M; Isenmann, S;
Indirizzi:
Dept Neurol, D-72076 Tubingen, Germany Dept Neurol Tubingen Germany D-72076 t Neurol, D-72076 Tubingen, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3353 - 3356
SICI:
0959-4965(20011029)12:15<3353:BINRIR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; ADULT-RATS; DEATH; APOPTOSIS; PROTECTION; LESION; CNS;
Keywords:
animal model; apoptosis; bcl-2; in vivo; knockout mouse; null mutation; optic nerve injury; neurodegeneration; retinal ganglion cell; retinotectal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Dietz, GPH Dept Neurol, Robert Koch Str 40, D-37075 Gottingen, Germany Dept Neurol Robert Koch Str 40 Gottingen Germany D-37075 rmany
Citazione:
G.P.H. Dietz et al., "Bcl-2 is not required in retinal ganglion cells surviving optic nerve axotomy", NEUROREPORT, 12(15), 2001, pp. 3353-3356

Abstract

Axotomy of the optic nerve in rodents induces the majority of retinal ganglion cells (RGCs) to undergo apoptosis: Only 10-15% survive 14 days past lesion. The molecular mechanism allowing this survival is not known. To test whether expression of the anti-apoptotic proto-oncogene bcl-2 gene is required in those RGCs, we examined the effect of optic nerve axotomy in bcl-2(-/-) mice. 7 days and 14 days post-lesion, the same number of surviving RGCswas detected in mutant and wild type retinas. Thus, the bcl-2 gene is not necessary for the survival of the subpopulation of retinal ganglion cells resisting axotomy-induced apoptosis in adult mice, nor does its normal expression delay retinal ganglion cell degeneration. NeuroReport 12:3353-3356 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 29/05/20 alle ore 11:25:10