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Titolo:
Focal cerebral ischemia causes two temporal waves of Akt activation
Autore:
Friguls, B; Justicia, C; Pallas, M; Planas, AM;
Indirizzi:
CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Farmacol & Toxicol, Barcelona 08036, Spain CSIC Barcelona Spain 08036 pt Farmacol & Toxicol, Barcelona 08036, Spain UB, Fac Farm, Dept Farmacol & Farmacognosia, Barcelona, Spain UB Barcelona Spain arm, Dept Farmacol & Farmacognosia, Barcelona, Spain
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3381 - 3384
SICI:
0959-4965(20011029)12:15<3381:FCICTT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; PROTEIN-KINASE; INFARCT VOLUME; CELL-DEATH; RAT-BRAIN; EXPRESSION; BCL-2; SURVIVAL; SIGNALS; BAD;
Keywords:
middle cerebral artery occlusion; protein kinase B; rat; time course;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Planas, AM CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Farmacol & Toxicol, Rossello 161,Planta 6, Barcelona 08036, Spain CSIC Rossello 161,Planta 6 Barcelona Spain 08036 08036, Spain
Citazione:
B. Friguls et al., "Focal cerebral ischemia causes two temporal waves of Akt activation", NEUROREPORT, 12(15), 2001, pp. 3381-3384

Abstract

We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylationof Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and alsoafter 1 h and 6 h of reperfusion, but it returned back to that in controlsby 24 h. After this first wave of Akt activation, a second increase was observed between 4 and 7 days. In striatum, only the late Akt activation was seen. In contrast to Akt, no Bad phosphorylation (serine-136) was detected after ischemia. Therefore, injury spontaneously activated Akt, but this didnot suppress Bad signalling. It is proposed that further pharmacological activation of Akt shortly after ischemia might promote cell survival, whereas Akt activation at longer time points is involved with glial reactivity. NeuroReport 12:3381-3384 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 00:19:04