Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Basic FGF localization in rat carotid body: paracrine role in O-2-chemoreceptor survival
Autore:
Paciga, M; Nurse, CA;
Indirizzi:
McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 ol, Hamilton, ON L8S 4K1, Canada
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3287 - 3291
SICI:
0959-4965(20011029)12:15<3287:BFLIRC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; NEURONAL DIFFERENTIATION; CHROMAFFIN CELLS; NEURAL CREST; NEURITE OUTGROWTH; PC12 CELLS; CHEMORECEPTORS; PROLIFERATION; EXPRESSION; DIVISION;
Keywords:
bFGF; FGF receptors; glomus cells; hypoxia; tyrosine hydroxylase; mitosis; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nurse, CA McMaster Univ, Dept Biol, 1280 Main St W, Hamilton, ON L8S 4K1, Canada McMaster Univ 1280 Main St W Hamilton ON Canada L8S 4K1 , Canada
Citazione:
M. Paciga e C.A. Nurse, "Basic FGF localization in rat carotid body: paracrine role in O-2-chemoreceptor survival", NEUROREPORT, 12(15), 2001, pp. 3287-3291

Abstract

Exposure of perinatal rat carotid body (CB) O-2-chemoreceptors to basic fibroblast growth factor (bFGF) or hypoxia in vitro increases mitotic activity. Using double-label immunofluorescence, we localized bFGF and its receptor (FGFR) to tyrosine hydroxylase-positive (TH+) chemoreceptors in vitro; bFGF immunoreactivity also localized to chemoreceptors in CB tissue sections. Mitotic activity, measured as percentage TH+ cells that took up bromodeoxyuridine, was relatively constant (similar to 29%) in normoxic (20% O-2) cultures. grown with or without bFGF neutralizing antibody (nAb). However, thenumber of surviving chemoreceptors was significantly reduced in nAb-treated cultures. Under chronic hypoxia (6% O-2), the presence of nAb significantly reduced chemoreceptor survival to similar to 70% of control, without affecting mitotic activity. Thus, autocrine/paracrine actions of endogenous bFGF may help promote CB chemoreceptor survival. NeuroReport 12:3287-3291 (C)2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:54:10