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Titolo:
Spinal GABA(B)-receptor antagonism increases nociceptive transmission in vivo
Autore:
Sokal, DM; Chapman, V;
Indirizzi:
Univ Nottingham, Sch Med, Sch Biomed Sci, Nottingham NG7 2UH, England UnivNottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 12, anno: 2001,
pagine: 3247 - 3250
SICI:
0959-4965(20011029)12:15<3247:SGAINT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS;
Keywords:
CGP-35348; GABA(B); nociception; rat; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Sokal, DM Univ Nottingham, Sch Med, Sch Biomed Sci, E Floor, Nottingham NG7 2UH, England Univ Nottingham E Floor Nottingham England NG7 2UH 2UH, England
Citazione:
D.M. Sokal e V. Chapman, "Spinal GABA(B)-receptor antagonism increases nociceptive transmission in vivo", NEUROREPORT, 12(15), 2001, pp. 3247-3250

Abstract

GABA(B) receptors modulate primary afferent fibre evoked responses of spinal neurones. Here effects of the selective GABA(B) receptor antagonist, CGP-35348, on electrically-evoked responses of spinal neurones in control and carrageenan-inflamed rats were studied. Spinal CGP-35348 (0.1-10 mug/50 mul) did not alter A beta- or A delta -fibre evoked neuronal responses in control rats, although C-fibre evoked responses and post discharge responses ofspinal neurones were significantly facilitated by 3.0 and 10.0 mug/50 mul CGP-35348 (p<0.05). In carrageenan-treated animals, spinal CGP-35348 did not alter electrically evoked responses of spinal neurones at any dose. Our data suggest that following acute peripheral inflammation there is loss of endogenous GABA(B) receptor mediated inhibition of C-fibre transmission at the level of the spinal cord. NeuroReport 12:3247-3250 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:13:50