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Titolo:
Sustained attention and inhibition of cognitive interference in treated phenylketonuria: associations with concurrent and lifetime phenylalanine concentrations
Autore:
Huijbregts, SCJ; de Sonneville, LMJ; Licht, R; van Spronsen, FJ; Verkerk, PH; Sergeant, JA;
Indirizzi:
Free Univ Amsterdam, Dept Clin Neuropsychol, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands Vrije Univ Amsterdam, Med Ctr, Pediat Outpatient Clin, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Univ Groningen Hosp, Beatrix Children Clin, Div Metab Dis, Dept Pediat, NL-9713 EZ Groningen, Netherlands Univ Groningen Hosp Groningen NetherlandsNL-9713 EZ ningen, Netherlands TNO Prevent & Hlth, Leiden, Netherlands TNO Prevent & Hlth Leiden Netherlands event & Hlth, Leiden, Netherlands
Titolo Testata:
NEUROPSYCHOLOGIA
fascicolo: 1, volume: 40, anno: 2002,
pagine: 7 - 15
SICI:
0028-3932(2002)40:1<7:SAAIOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA PHENYLALANINE; EXECUTIVE FUNCTION; DIETARY-TREATMENT; BRAIN-FUNCTION; CHILDREN; VIGILANCE; DEFICITS; HYPERPHENYLALANINEMIA; SPECTROSCOPY; PERFORMANCE;
Keywords:
PKU; executive function; cognitive development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Huijbregts, SCJ Free Univ Amsterdam, Dept Clin Neuropsychol, Van Der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Van Der Boechorststr 1 Amsterdam Netherlands NL-1081 BT
Citazione:
S.C.J. Huijbregts et al., "Sustained attention and inhibition of cognitive interference in treated phenylketonuria: associations with concurrent and lifetime phenylalanine concentrations", NEUROPSYCHO, 40(1), 2002, pp. 7-15

Abstract

Fifty-seven 7-14-year-old early- and continuously treated phenylketonuria (PKU) patients and 65 matched controls performed a sustained attention task. PKU patients with plasma phenylalanine (phe) levels higher than 360 mu mol/l at the time of testing exhibited, compared to controls, lower speed of information processing, a lower ability to inhibit task-induced cognitive interference, less consistent performance, and a stronger decrease of performance level over time. Patients with concurrent phe levels lower than 360 mu mol/l did not differ from controls and were significantly better than patients with levels higher than 360 mu mol/l. Strong relationships were foundwith task performance for phe levels during the pre-school years and between ages 5 and 7. These correlations were stronger than those between concurrent phe level and task performance. Significant multiple regression modelswere found with age accounting for the largest proportion of variance of tempo and tempo fluctuation, and lifetime phe levels (particularly phe levelbetween ages 5 and 7) accounting for the largest proportion of variance ofthe relative number of inhibition errors and its increase over time. Phe level between ages 5 and 7 also contributed significantly to the variance oftempo and tempo fluctuation. Neuropsychological outcome was independent ofIQ. The results indicate that strict dietary adherence during these periods is beneficial to attentional control later in life. We suggest that phe levels should be maintained under 360 mu mol/l until approximately age 12, when development of attentional control approaches an adult level. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:08:49