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Titolo:
Stimulus timing-dependent plasticity in cortical processing of orientation
Autore:
Yao, HS; Dan, Y;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 urobiol, Berkeley, CA 94720 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 32, anno: 2001,
pagine: 315 - 323
SICI:
0896-6273(20011025)32:2<315:STPICP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; UNDERLYING CONTRAST ADAPTATION; PRIMARY VISUAL-CORTEX; CAT STRIATE CORTEX; SYNAPTIC DEPRESSION; RESPONSE AMPLITUDE; PYRAMIDAL CELLS; SELECTIVITY; NEURONS; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dan, Y Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 229 Stanley Hall Berkeley CA USA 94720 4720 USA
Citazione:
H.S. Yao e Y. Dan, "Stimulus timing-dependent plasticity in cortical processing of orientation", NEURON, 32(2), 2001, pp. 315-323

Abstract

The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orientation tuning of cat cortical neurons, with the directionof the shift depending on the temporal order of the pair. Induction of a significant shift required that the interval between the pair fall within +/-40 ms, reminiscent of the temporal window for spike timing-dependent synaptic plasticity. Mirroring the plasticity found in cat visual cortex, similar conditioning also induced a shift in perceived orientation by human subjects, further suggesting functional relevance of this phenomenon. Thus, relative timing of visual stimuli can play a critical role in dynamic modulation of adult cortical function, perhaps through spike timing-dependent synaptic plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:03:08