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Titolo:
Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system
Autore:
Clandinin, TR; Lee, CH; Herman, T; Lee, RC; Yang, AY; Ovasapyan, S; Zipursky, SL;
Indirizzi:
Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Biol Chem, Sch Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 32, anno: 2001,
pagine: 237 - 248
SICI:
0896-6273(20011025)32:2<237:DLRRAR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE PHOSPHATASES; MOTOR AXON GUIDANCE; NERVOUS-SYSTEM; IN-VIVO; PTP-MU; BRAKELESS; EMBRYO; RETINA; DLAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Zipursky, SL Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Biol Chem, Sch Med, 5-748 MRL,675 Charles Young Dr S, Los Angeles, CA 90095 USA Univ Calif Los Angeles 5-748 MRL,675 Charles Young Dr S Los Angeles CA USA 90095
Citazione:
T.R. Clandinin et al., "Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system", NEURON, 32(2), 2001, pp. 237-248

Abstract

Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye connect to specific targets in the optic lobe. Using a behavioralscreen, we identified LAR, a receptor tyrosine phosphatase, as being required for R cell target specificity. In LAR mutant mosaic eyes, R1-R6 cells target to the lamina correctly, but fail to choose the correct pattern of target neurons. Although mutant R7 axons initially project to the correct layer of the medulla, they retract into inappropriate layers. Using single cell mosaics, we demonstrate that LAR controls targeting of R1-R6 and R7 in a cell-autonomous fashion. The phenotypes of LAR mutant R cells are strikingly similar to those seen in N-cadherin mutants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:56:49