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Titolo:
Selectively impaired reaction time in Parkinson's disease: Persistent absence of simple reaction advantage in a patient with frontal complications
Autore:
Henderson, L; Harrison, J; Kennard, C;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Sch Med, Div Neurosci & Psychol Med, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med London England W6 8RF ngland CeNeS Ltd, Cambridge CB4 9ZR, England CeNeS Ltd Cambridge England CB4 9ZR eNeS Ltd, Cambridge CB4 9ZR, England
Titolo Testata:
NEUROCASE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 319 - 330
SICI:
1355-4794(2001)7:4<319:SIRTIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPLEMENTARY MOTOR AREA; INFERIOR PREFRONTAL CORTEX; DEEP BRAIN-STIMULATION; SACCADIC EYE-MOVEMENTS; REMEMBERED SACCADES; WORKING-MEMORY; ACTIVATION; PERFORMANCE; ABNORMALITIES; BRADYPHRENIA;
Keywords:
simple reaction time (RT); choice RT; simpler reaction advantage; stimulus and response uncertainty; Parkinson's disease (PD); frontal lobe disorders; Wisconsin Card Sort Test (WCST);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Henderson, L 4 Manor View, Huntingdon PE29 1WD, Cambs, England 4 Manor View Huntingdon Cambs England PE29 1WD ambs, England
Citazione:
L. Henderson et al., "Selectively impaired reaction time in Parkinson's disease: Persistent absence of simple reaction advantage in a patient with frontal complications", NEUROCASE, 7(4), 2001, pp. 319-330

Abstract

The search for specific patterns of impaired reaction time in Parkinson's disease has yielded conflicting results. We propose subtypes that exhibit different patterns of impairment and report the case of a patient, Jobe, whose simple and binary choice reaction times were tested repeatedly in a variety of stimulus-response paradigms over a period of 4 years. Jobe consistently failed to exhibit the normal simple reaction advantage even though his choice reaction times fell well within the normal range. While his general intellectual status was above average, he had great difficulty with some neuropsychological tests. He was seldom able to acquire a new category in theWisconsin Card Sort Test and also had difficulty with the Tower of London Test. We ascribe Jobe's selective impairment of simple reactions to an inability to engage in the off-line preparatory processing that confers an advantage on simple reactions.

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Documento generato il 29/03/20 alle ore 09:25:03