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Titolo:
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Autore:
Matsuzaki, M; Ellis-Davies, GCR; Nemoto, T; Miyashita, Y; Iino, M; Kasai, H;
Indirizzi:
Natl Inst Physiol Sci, Dept Cell Physiol, Okazaki, Aichi 4448585, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 i, Aichi 4448585, Japan Grad Univ Adv Studies, Okazaki, Aichi 4448585, Japan Grad Univ Adv Studies Okazaki Aichi Japan 4448585 i, Aichi 4448585, Japan Japan Sci & Technol Corp, CREST, Bunkyo Ku, Tokyo 1130033, Japan Japan Sci& Technol Corp Tokyo Japan 1130033 yo Ku, Tokyo 1130033, Japan Univ Tokyo, Sch Med, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Sch Med, Bunkyo Ku, Tokyo 1130033, Japan Med Coll Penn & Hahnemann Univ, Dept Physiol & Pharmacol, Philadelphia, PA19102 USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19102 hia, PA19102 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 11, volume: 4, anno: 2001,
pagine: 1086 - 1092
SICI:
1097-6256(200111)4:11<1086:DSGICF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; 2-PHOTON EXCITATION; GLUTAMATE RECEPTORS; SURFACE EXPRESSION; SILENT SYNAPSES; CROSS-SECTIONS; NMDA RECEPTORS; NONSATURATION; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kasai, H Natl Inst Physiol Sci, Dept Cell Physiol, Okazaki, Aichi 4448585,Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 4448585, Japan
Citazione:
M. Matsuzaki et al., "Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons", NAT NEUROSC, 4(11), 2001, pp. 1086-1092

Abstract

Dendritic spines serve as preferential sites of excitatory synaptic connections and are pleomorphic. To address the structure-function relationship of the dendritic spines, we used two-photon uncaging of glutamate to allow mapping of functional glutamate receptors at the level of the single synapse. Our analyses of the spines of CA1 pyramidal neurons reveal that AMPA (alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-type glutamate receptors are abundant (up to 150/spine) in mushroom spines but sparsely distributed in thin spines and filopodia. The latter may be serving as the structural substrates of the silent synapses that have been proposed to play roles in development and plasticity of synaptic transmission. Our data indicatethat distribution of functional AMPA receptors is tightly correlated with spine geometry and that receptor activity is independently regulated at thelevel of single spines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:32:19