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Titolo:
Elevated in vivo frequencies of mutant T cells with altered functional expression of the T-cell receptor or hypoxanthine phosphoribosyltransferase genes in p53-deficient mice
Autore:
Suzuki, T; Kusunoki, Y; Tsuyama, N; Ohnishi, H; Seyama, T; Kyoizumi, S;
Indirizzi:
Radiat Effects Res Fdn, Dept Radiobiol, Hiroshima 7320815, Japan Radiat Effects Res Fdn Hiroshima Japan 7320815 Hiroshima 7320815, Japan
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 483, anno: 2001,
pagine: 13 - 17
SICI:
1386-1964(20011101)483:1-2<13:EIVFOM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; LYMPHOCYTES-T; P53; MOUSE; MUTATIONS; LOCUS;
Keywords:
p53; somatic mutation; ionizing radiation; HPRT; T-cell receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kyoizumi, S Radiat Effects Res Fdn, Dept Radiobiol, 5-2 Hijiyama Pk, Hiroshima 7320815, Japan Radiat Effects Res Fdn 5-2 Hijiyama Pk Hiroshima Japan7320815
Citazione:
T. Suzuki et al., "Elevated in vivo frequencies of mutant T cells with altered functional expression of the T-cell receptor or hypoxanthine phosphoribosyltransferase genes in p53-deficient mice", MUT RES-F M, 483(1-2), 2001, pp. 13-17

Abstract

We have studied the effects of a defect in the p53 gene on spontaneous andradiation-induced somatic mutation frequencies in vivo by measuring T-cellreceptor (TCR) and hypoxanthine phosphoribosyltransferase (HPRT) mutant frequencies (MFs) in p53 deficient mice both before and after exposure to X-irradiation. In the absence of irradiation, the TCR and HPRT mutant frequencies were roughly two-fold higher in p53 null (-/-) mice than in wild-type (/+) mice. Unexpectedly, the TCR and HPRT MFs were slightly lower in heterozygote p53 (+/-) than in wild-type (+/+) mice., however. After 2 weeks 2 Gywhole body irradiation the TCR and HPRT MFs were about two-fold higher in the p53 null (-/-) and p53 (+/-) mice than in the wild-type. Taken together, these findings suggest that a defect in the p53 gene may lead to TCR and HPRT mutants being recovered at higher frequencies in both irradiated and unirradiated mice, but it should be emphasized that the effects we have observed are not particularly strong, albeit that they are statistically significant. Interestingly, several of the highest TCR MF values that we observedin the course of our experiments were recorded in p53 (-/-) animals that had developed thymomas and hence appeared to be cancer prone. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:59:59