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Titolo:
Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis
Autore:
Puri, PL; Iezzi, S; Stiegler, P; Chen, TT; Schiltz, RL; Muscat, GEO; Giordano, A; Kedes, L; Wang, JYJ; Sartorelli, V;
Indirizzi:
Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA Univ Roma La Sapienza, Gene Express Lab, Fdn Andrea Cesalpino, I-00161 Rome, Italy Univ Roma La Sapienza Rome Italy I-00161 Cesalpino, I-00161 Rome, Italy NIAMSD, Muscle Biol Lab, Muscle Gene Express Grp, NIH, Bethesda, MD 20892 USA NIAMSD Bethesda MD USA 20892 ene Express Grp, NIH, Bethesda, MD 20892 USA Thomas Jefferson Univ, Jefferson Med Coll, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Univ Queensland, Ctr Cellular & Mol Biol, Ritchie Res Labs, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 St Lucia, Qld 4072, Australia Univ So Calif, Inst Genet Mol, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ol Biol, Los Angeles, CA 90033 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 8, anno: 2001,
pagine: 885 - 897
SICI:
1097-2765(200110)8:4<885:CIHDSI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE ARREST; MEF2 TRANSCRIPTION FACTOR; MUSCLE GENE-EXPRESSION; RETINOBLASTOMA PROTEIN; TERMINAL DIFFERENTIATION; REPRESS TRANSCRIPTION; BINDING; RB; P300; ACETYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Puri, PL Salk Inst Biol Studies, Peptide Biol Lab, La Jolla, CA 92093 USA Salk Inst Biol Studies La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
P.L. Puri et al., "Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis", MOL CELL, 8(4), 2001, pp. 885-897

Abstract

We describe a functional and biochemical link between the myogenic activator MyoD, the deacetylase HDAC1, and the tumor suppressor pRb. Interaction of MyoD with HDAC1 in undifferentiated myoblasts mediates repression of muscle-specific gene expression. Prodifferentiation cues, mimicked by serum removal, induce both downregulation of HDAC1 protein and pRb hypophosphorylation. Dephosphorylation of pRb promotes the formation of pRb-HDAC1 complex indifferentiated myotubes. pRb-HDAC1 association coincides with disassembling of MyoD-HDAC1 complex, transcriptional activation of muscle-restricted genes, and cellular differentiation of skeletal myoblasts. A single point mutation introduced in the HDAC1 binding domain of pRb compromises its abilityto disrupt MyoD-HDAC1 interaction and to promote muscle gene expression. These results suggest that reduced expression of HDAC1 accompanied by its redistribution in alternative nuclear protein complexes is critical for terminal differentiation of skeletal muscle cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:44:09