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Titolo:
Targeted disruption of the zeta PKC gene results in the impairment of the NF-kappa B pathway
Autore:
Leitges, M; Sanz, L; Martin, P; Duran, A; Braun, U; Garcia, JF; Camacho, F; Diaz-Meco, MT; Rennert, PD; Moscat, J;
Indirizzi:
Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain Ctr Biol Mol Severo Ochoa Madrid Spain 28049 Ochoa, Madrid 28049, Spain Max Planck Inst Expt Endokrinol, D-30625 Hannover, Germany Max Planck InstExpt Endokrinol Hannover Germany D-30625 nnover, Germany Ctr Nacl Investigac Oncol, Madrid 28220, Spain Ctr Nacl Investigac Oncol Madrid Spain 28220 Oncol, Madrid 28220, Spain Biogen Inc, Cambridge, MA 02142 USA Biogen Inc Cambridge MA USA 02142Biogen Inc, Cambridge, MA 02142 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 8, anno: 2001,
pagine: 771 - 780
SICI:
1097-2765(200110)8:4<771:TDOTZP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; SEVERE LIVER DEGENERATION; INDUCED CELL-DEATH; MICE LACKING; TRANSCRIPTIONAL ACTIVITY; EMBRYONIC LETHALITY; SIGNAL-TRANSDUCTION; PATCH ORGANOGENESIS; DEFICIENT MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Moscat, J Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain Ctr Biol Mol Severo Ochoa Madrid Spain 28049 drid 28049, Spain
Citazione:
M. Leitges et al., "Targeted disruption of the zeta PKC gene results in the impairment of the NF-kappa B pathway", MOL CELL, 8(4), 2001, pp. 771-780

Abstract

Here we have addressed the role that PKC plays in NF-kappaB activation using mice in which this kinase was inactivated by homologous recombination. These mice, although grossly normal, showed phenotypic alterations in secondary lymphoid organs reminiscent of those of the TNF receptor-1 and of the lymphotoxin-beta receptor gene-deficient mice. The lack of xi PKC in embryonic fibroblasts (EFs) severely impairs kappaB-dependent transcriptional activity as well as cytokine-induced phosphorylation of p65. Also, a cytokine-inducible interaction of xi PKC with p65 was detected which requires the previous degradation Of I kappaB. Although in xi PKC-/- EFs this kinase is notnecessary for IKK activation, in lung, which abundantly expresses xi PKC, IKK activation is inhibited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:31:13