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Titolo:
Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern
Autore:
Wolfer, DP; Lang, R; Cinelli, P; Madani, R; Sonderegger, P;
Indirizzi:
Univ Zurich, Inst Anat, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 Anat, CH-8057 Zurich, Switzerland Univ Zurich, Inst Biochem, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 chem, CH-8057 Zurich, Switzerland
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 18, anno: 2001,
pagine: 407 - 433
SICI:
1044-7431(200110)18:4<407:MRONIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CALLOSAL PROJECTION NEURONS; EARLIEST GENERATED CELLS; ACTIVATOR MESSENGER-RNA; DORSAL-ROOT GANGLIA; PLASMINOGEN-ACTIVATOR; NEURITE OUTGROWTH; SCHWANN-CELLS; CEREBRAL-CORTEX; CORPUS-CALLOSUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Wolfer, DP Univ Zurich, Inst Anat, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 57 Zurich, Switzerland
Citazione:
D.P. Wolfer et al., "Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern", MOL CELL NE, 18(4), 2001, pp. 407-433

Abstract

We have mapped the spatio-temporal expression of the multidomain serine protease neurotrypsin in the developing mouse by In situ hybridization. On embryonic day (E) 8, mRNA is detected in giant trophoblast cells, later in embryonic mesenchymal tissues. On Ell, expression begins in Schwann cell precursors, olfactory epithelium, trigeminal ganglion, and midbrain. The floor plate shows strong expression on E12. Further prenatal development is characterized by rising neurotrypsin mRNA in sensory ganglia and motor neurons. Staining in cerebral cortex emerges around birth and culminates toward the end of the first week with a complex laminar and areal pattern. Expression in peripheral nerves and nonneural tissues vanishes soon after birth and the adult neuronal distribution is gradually established until weaning age. This developmental expression pattern suggests roles of neurotrypsin in morphogenesis of nonneural tissues, as well as in neural development, in particular in axonal target invasion, synaptogenesis, and Schwann cell differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:28:46