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Titolo:
Evaluation of the usefulness of Internet searches to identify unpublished clinical trials for systematic reviews
Autore:
Eysenbach, G; Tuische, J; Diepgen, TL;
Indirizzi:
Univ Heidelberg, Dept Clin Social Med, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany
Titolo Testata:
MEDICAL INFORMATICS AND THE INTERNET IN MEDICINE
fascicolo: 3, volume: 26, anno: 2001,
pagine: 203 - 218
SICI:
1463-9238(200107/09)26:3<203:EOTUOI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSERTIVE COMMUNITY TREATMENT; RANDOMIZED CONTROLLED TRIAL; SEVERE MENTAL-ILLNESS; PUBLICATION BIAS; HEALTH-CARE; INFORMATION; WEB; METAANALYSIS; MANAGEMENT; REGISTRY;
Keywords:
information storage and retrieval; Internet; data collection; meta-analysis; clinical trials; evaluation studies; publication bias; recall; precision; evidence-based medicine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Eysenbach, G Univ Heidelberg, Dept Clin Social Med, Bergheimer Str 58, D-69115 Heidelberg, Germany Univ Heidelberg Bergheimer Str 58 Heidelberg Germany D-69115
Citazione:
G. Eysenbach et al., "Evaluation of the usefulness of Internet searches to identify unpublished clinical trials for systematic reviews", MED INF IN, 26(3), 2001, pp. 203-218

Abstract

Primary objective: To avoid selection and publication bias, systematic reviewers should employ a broad range of search techniques and make efforts tolocate unpublished studies. We tried to establish whether searches on the World Wide Web (WWW) are useful to identify additional unpublished and ongoing clinical trials. Research design: Search strategies of seven Cochrane systematic reviews were retrospectively adapted for the WWW in an attempt to find additional randomized controlled trials. Methods and procedures: A search strategy with the general pattern 'study methodology NEAR intervention NEAR condition' for the Internet search engine AltaVista was evaluated by measuring search time, recall of Internet searches for published studies; precision (proportion of webpages containing hints to relevant published and unpublished randomized clinical trials); number of additional unpublished or ongoing studies found on the Internet. Main outcomes and results: We reviewed 429 webpages in 21 hours and found hints to 14 unpublished, ongoing or recently finished trials, at least 9 were considered relevant for 4 systematic reviews. The recall of Internet searches to find references to published studies ranged between 0%, and 43.6%,the precision for hints to published or unpublished studies range between 0% and 20.2%. Conclusions: Information on unpublished and particularly ongoing trials can be found on the Internet. A potential problem is the appraisal of non-peer reviewed electronic publications with questionable quality. More powerfulsearch tools are needed. An 'Open Trial Initiative' is proposed to define a syntax for publishing trials on the web and to ensure interoperability oftrial registers, so that special search engines can harvest information onongoing and complete clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 01:00:53