Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Albumin-bound MRI contrast agents: the dilemma of the rotational correlation time
Autore:
Vander Elst, L; Laurent, S; Bintoma, HM; Muller, RN;
Indirizzi:
Univ Mons, NMR Lab, Dept Organ Chem, B-7000 Mons, Belgium Univ Mons MonsBelgium B-7000 Lab, Dept Organ Chem, B-7000 Mons, Belgium
Titolo Testata:
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
fascicolo: 2-3, volume: 12, anno: 2001,
pagine: 135 - 140
SICI:
0968-5243(200105)12:2-3<135:AMCATD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SERUM-ALBUMIN; MAGNETIC-RESONANCE; FLUORESCENCE; DYNAMICS; PROTEINS; BINDING; DRUGS;
Keywords:
MRI; contrast agents; non-covalent binding; albumin; deuterium NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, RN Univ Mons, NMR Lab, Dept Organ Chem, B-7000 Mons, Belgium Univ Mons Mons Belgium B-7000 rgan Chem, B-7000 Mons, Belgium
Citazione:
L. Vander Elst et al., "Albumin-bound MRI contrast agents: the dilemma of the rotational correlation time", MAGN RES MA, 12(2-3), 2001, pp. 135-140

Abstract

Human serum albumin (HSA) binds numerous molecules, among which are suitably designed MRI contrast agents. The rotational tumbling of the protein is thus one of the parameters likely to affect the in vivo relaxivity of theseagents. Literature unveils discrepancies about the value of the rotationalcorrelation time (tau (R)) of HSA. In the present work, the tau (R), of this protein has been determined by studying the deuterium relaxation rate ofsmall molecules known for their strong binding to HSA (warfarin and 4-hydroxycoumarin). Values of approx. 20-22 ns are obtained at 310 K in a 4% HSA solution and are in good agreement with the theoretical predictions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:42:19