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Titolo:
P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results
Autore:
Port, M; Corot, C; Rousseaux, O; Raynal, I; Devoldere, L; Idee, JM; Dencausse, A; Le Greneur, S; Simonot, C; Meyer, D;
Indirizzi:
Guerbet, Chem Res, F-95943 Roissy CDG, France Guerbet Roissy CDG France F-95943 , Chem Res, F-95943 Roissy CDG, France
Titolo Testata:
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
fascicolo: 2-3, volume: 12, anno: 2001,
pagine: 121 - 127
SICI:
0968-5243(200105)12:2-3<121:PARCBP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR CONTRAST AGENTS; GD-DTPA; ANGIOGRAPHY; COMPLEXES; PHARMACOKINETICS; RABBITS; DOTA;
Keywords:
MRI blood pool contrast agent; gadolinium macrocycle; chemistry; relaxivity; pharmacokinetics; acute toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Port, M Guerbet, Chem Res, BP 50400, F-95943 Roissy CDG, France Guerbet BP50400 Roissy CDG France F-95943 943 Roissy CDG, France
Citazione:
M. Port et al., "P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results", MAGN RES MA, 12(2-3), 2001, pp. 121-127

Abstract

An original MRI contrast agent, called P792, is described. P792 is a gadolinium macrocyclic compound based on a Gd-DOTA structure substituted by hydrophilic arms. The chemical structure of P792 has been optimized in order toprovide (1) a high r(1) relaxivity in the clinical field for MRI: 29 mM(-1) x s(-1) at 60 MHz, (2) a high biocompatibility profile and (3) a high molecular volume: the apparent hydrodynamic volume of P792 is 125 times greater than that of Gd-DOTA. As a result of this high molecular volume, P792 presents an unusual pharmacokinetic profile, as it is a Rapid Clearance Blood Pool Agent (RCBPA) characterized by limited diffusion across the normal endothelium. The original pharmacokinetic properties of this RCBPA are expected to be well suited to MR coronary angiography, angiography, perfusion imaging (stress and rest), and permeability imaging (detection of ischemia and tumor grading). Further experimental imaging studies are ongoing to define the clinical value of this compound. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:07:05