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Titolo:
Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea
Autore:
Genazzani, AD; Bersi, C; Luisi, S; Fruzzetti, F; Malavasi, B; Luisi, M; Petraglia, F; Genazzani, AR;
Indirizzi:
Univ Modena, Dept Obstet & Gynecol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Obstet & Gynecol, I-41100 Modena, Italy Univ Siena, Chair Obstet & Gynecol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 ir Obstet & Gynecol, I-53100 Siena, Italy CNR, Endocrine Res Unit, I-56100 Pisa, Italy CNR Pisa Italy I-56100CNR, Endocrine Res Unit, I-56100 Pisa, Italy Univ Pisa, Dept Reprod Med & Child Dev, Sect Gynecol Obstet, Pisa, Italy Univ Pisa Pisa Italy Med & Child Dev, Sect Gynecol Obstet, Pisa, Italy
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 3, volume: 78, anno: 2001,
pagine: 247 - 252
SICI:
0960-0760(200109)78:3<247:IASSIR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; LUTEINIZING-HORMONE SECRETION; STRESS; HYPERCORTISOLISM; INHIBITION; AXIS;
Keywords:
adrenal steroids; adrenocorticotropin hormone; corticotropin-releasing hormone; hypothalamic amenorrhea; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Genazzani, AD Univ Modena, Dept Obstet & Gynecol, Via Pozzo 71, I-41100 Modena, Italy Univ Modena Via Pozzo 71 Modena Italy I-41100 Modena, Italy
Citazione:
A.D. Genazzani et al., "Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea", J STEROID B, 78(3), 2001, pp. 247-252

Abstract

Objective: To evaluate adrenal steroid hormone secretion in response to corticotropin-releasing factor (CRF) or to adrenocorticotropin hormone in women with hypothalamic amenorrhea. Design: Controlled clinical study. Setting: Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Italy. Patient(s): Fifteen women with hypothalamic amenorrhea were enrolled in the study. Eight normal cycling women were used as control group. Intervention(s): Blood samples were collected before and after an injection of ovine CRF (0.1 mug/kg iv bolus) or after synthetic ACTH (0.25 mg iv). Main outcome measure(s): Plasma levels of ACTH, 17-hydroxypregnenolone (17OHPe), progesterone (P), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17OHP), cortisol (F), 11-deoxycortisol (S) and androstenedione (A). Result(s): Basal plasma concentrations of ACTH, cortisol, 11-deoxycortisol, DHEA and 17OHPe were significantly higher in patients than in controls, whereas plasma levels of progesterone and 17-OHP were significantly lower in patients than in controls. In amenorrheic women the ratio of 17-OHPe/DHEA, of 17-OHPe/17-OHP and of 11-deoxycortisol/cortisol were significantly higher than in controls, while a significant reduction in the ratio of 17-OHP/androstenedione, of 17-OHP/11-deoxycortisol was obtained. In response to corticotropin-releasing factor test, plasma levels of ACTH, cortisol, 17-OHP, 11-deoxycortisol, DHEA and androstenedione were significantly lower in patients than in controls. In response to adrenocorticotropin hormone, plasma levels of 17-OHP, androstenedione and androstenedione/cortisol were significantly higher in patients than in controls. Conclusions: Patients suffering for hypothalamic amenorrhea showed an increased activation of hypothalamus-pituitary-adrenal (HPA) axis, as shown bythe higher basal levels and by augmented adrenal hormone response to corticotropin-releasing factor administration. These data suggest a possible derangement of adrenal androgen enzymatic pathway. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 04/04/20 alle ore 00:21:12