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Titolo:
Expression of the MT1 melatonin receptor subtype in human coronary arteries
Autore:
Ekmekcioglu, C; Haslmayer, P; Philipp, C; Mehrabi, MR; Glogar, HD; Grimm, M; Leibetseder, VJ; Thalhammer, T; Marktl, W;
Indirizzi:
Univ Vienna, Sch Med, Dept Physiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Physiol, A-1090 Vienna, Austria Univ Vienna, Gen Hosp AKH, Dept Pathophysiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Pathophysiol, A-1090 Vienna, Austria Univ Vienna, Gen Hosp AKH, Dept Cardiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Cardiol, A-1090 Vienna, Austria Univ Vienna, Gen Hosp AKH, Dept Cardiothorac Surg, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 diothorac Surg, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
fascicolo: 1, volume: 21, anno: 2001,
pagine: 85 - 91
SICI:
1079-9893(200102)21:1<85:EOTMMR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE WISTAR RATS; TAIL ARTERY; MECHANISMS; DISEASE;
Keywords:
melatonin receptors; human coronary arteries;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ekmekcioglu, C Univ Vienna, Sch Med, Dept Physiol, Schwarzspanierstr 17, A-1090 Vienna, Austria Univ Vienna Schwarzspanierstr 17 Vienna Austria A-1090 ria
Citazione:
C. Ekmekcioglu et al., "Expression of the MT1 melatonin receptor subtype in human coronary arteries", J RECEPT SI, 21(1), 2001, pp. 85-91

Abstract

Previous experimental data suggest a possible influence of melatonin on the circulatory system of animals after binding to G-protein coupled melatonin receptors. The present study sought to investigate whether the melatonin receptor, mt(1), is expressed in human coronary arteries derived from healthy heart donors (n = 8). Expression of the mt(1)-receptor was studied in sections of isolated coronary arteries by a reverse transcriptase-polymerase chain reaction (RT-PCR) and Western immunoblot technique. The analyses of the results from both methods indicated the presence of the mt(1)-receptor in all of the subjects. Referring to these data we assume that melatonin regulates physiological processes in human coronary arteries after receptor binding.

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Documento generato il 25/01/20 alle ore 16:17:15