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Titolo:
AUTISTIC BEHAVIORS AMONG GIRLS WITH FRAGILE-X-SYNDROME
Autore:
MAZZOCCO MMM; KATES WR; BAUMGARDNER TL; FREUND LS; REISS AL;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,KENNEDY KRIEGER INST,BEHAV NEUROGENET & NEUROIMAGING RES CTR BALTIMORE MD 21205
Titolo Testata:
Journal of autism and developmental disorders
fascicolo: 4, volume: 27, anno: 1997,
pagine: 415 - 435
SICI:
0162-3257(1997)27:4<415:ABAGWF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FMR-1 FULL MUTATION; DSM-III-R; INFANTILE-AUTISM; POSTERIOR-FOSSA; CEREBELLAR; PHENOTYPE; FEMALES; ABNORMALITIES; MALES; NEUROBIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
M.M.M. Mazzocco et al., "AUTISTIC BEHAVIORS AMONG GIRLS WITH FRAGILE-X-SYNDROME", Journal of autism and developmental disorders, 27(4), 1997, pp. 415-435

Abstract

Reports of autistic behaviors were examined for 30 school-age girls with fragile X (fraX) and 31 age- and IQ-matched controls through a structured interview administered to each girl's parent(s). IQ scores were obtained for each participant; anxiety neuroanatomical, and molecular-genetic data were derived for girls with fraX. Girls with fraX had significantly more autistic behaviors than controls, These behaviors were qualitatively similar to those reported for boys with fraX, but were not correlated with IQ. Anxiety in girls with fraX was positively correlated with abnormal social and communication behaviors; posterior cerebellar vermis area was negatively correlated with measures of communication and stereotypic/restricted behaviors. Severity of stereotypic/restricted behaviors was negatively correlated with the prevalence ofactive non-fraX chromosomes, Thus anxiety and posterior cerebellar area measures had distinct associations with subsets of autistic behaviors; these associations may have important implications for understanding the neurobiology of autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:00:38